Phosphine Promoted Reaction Between Modified Allyl Compounds And Trifluoromethyl Aryl Ketone

As a substitute of olefine acid ester,the allyl alcohol derivatives whichpreparation by Morita-Baylis-hilleman reaction is a important synthon ofnucleophilic catalytic synthesis.It can be used as nucleophilic three carbonWith various electrophilic reagents in [3+x](x=2,3,4,6) of the cycloaddition,orwork as a both sexes of a carbon source With conjugate electrophilic reagentsor bifunctional reagent in [1+4] cyclization reaction.But it rare that amolecular MBH reaction derivative twice nucleophilic attack react with twomolecules of electrophilic reagents.1. the biologically active molecule containing trifluoromethyl mayexhibit unique physical, chemical and physiological properties, and thus thechemical biology and drug discovery has wide potential application ofresearch. Development trifluoromethyl carbonyl compound using a series ofreaction of electrophilic fluorine blocks can range from simple and readilyavailable starting material a compound of relatively complex high efficiency.In this paper, the tandem reaction of allyl compound and phosphine promotedlactonization/wittig trifluoromethyl carbonyl compound to give the lactone-containing compound series alkenyl carbon trifluoromethyl quarter.2. the study found that the reaction, the resulting lactone product mayoccur with further ester MBH cycloaddition reaction to give a one-potcontaining an oxygen heteroatom and trifluoromethyl quaternary carbon ringcompound, from two molecules of trifluoromethanesulfonic ketones andesters MBH two molecules involved in the reaction. Further work will focuson the chemical selectivity can be regulated to achieve tandem reaction carriedout.