Synthesis Of Novel Heterocyclic Compounds Based On4-hydroxycoumarin

With further study of people, coumarin derivative compound are appearedincreasingly, coumarin derivative are used as additives in food additives, flavors, cosmetics,pharmaceuticals, platelet aggregation and agricultural chemicals, and also has anticancer,anti-HIV, anticlotting effect. Because of its unique photochemical and photophysicalproperties, coumarin derivative also can be used as dyes, pigments and organic fluorescentmaterial. Therefore, synthesizing of more coumarin compounds will have a greatsignificance in people’s lives.First of all, we used the4-hydroxycoumarin as raw material to synthesis of3-acetyl-4-hydroxycoumarin, and basising on this we synthesised of a series ofcoumarino[4,3-b]pyran-4-one derivatives through aldol condensation and intramolecularcyclization process.Secondly, we used the3-bromoacetyl-4-hydroxycoumarin as raw materials andreacted with aldehyde to synthesis of a series of2-phenyldene-5H-furo[3,2-c]coumarin-3-onederivatives under the optimized reaction conditions.Finally, we used4-chloro-7-methyl-coumarin and reactioned with aldehyde tosynthesis of a series of4-(3-amino-thieno[2,3-b]pyridin-2-yl)coumarins derivatives in thepresence of p-Toluenesulfonic acid.The structures of all compounds were characterized by1HNMR、13CNMR and IRspectrum.