Study On The Synthesis Of Pyrrole And Triazole Compounds By Multicomponent Reactions

Nitrogen-containing heterocyclic compounds are of great importance in organicand pharmaceutical synthesis. They always are intermediates and building blocks inmany bioactive molecules and natural products. In recent years, organic chemistsand researchers have paid more attention to the synthesis of nitrogen-containingheterocyclic compounds.Substituted pyrroles and triazoles, both as key five-member nitrogen-containingheterocyclic compounds, exhibit a variety of physiological activity, such asantibacterial, anti-inlfammatory and antioxidant. In the thesis, the fast and highlyefficient synthesis of substituted l，2，3-triazoles and pyrroles were investigated bymulticomponent reaction and green chemistry methods.The thesis includes three chapters.Chapter1: Literature survey.In this chapter we reviewed the comprehensive syntheses and applications ofpyrroles and triazoles compounds.Chapter2: Copper nanoparticles catalyzed synthesis of l，2，3-triazole compoundsA one-pot synthetic protocol of1-benzyl-4-phenyl-1,2,3-triazoles fromphenylacetylene, sodium azide and benzyl halides catalyzed by copper metalnanoparticles was developed. Compared with the literatures reported, the method issimple, mild, and easy to get raw materials.Chapter3: Novel synthesis of substituted pyrrole compoundsA novel synthesis of alkyl substituted pyrroles from aliphatic aldehydes andnitroalkanes catalyzed by ferric chloride in the presence of aniline was investigated.The good product yields were obtained. The reaction conditions were also optimized.The advantages of this procedure include easily obtained raw materials, simpleoperation, low cost and mild reaction conditions.