The Application Of Supported Copper(Ⅰ) Catalyst In Click Reaction And Synthesis Of Dendrimer

1,2,3-triazole compounds are a class of heterocyclic compounds withpharmacological activity. CuAAC reaction is the main method for thesynthesis of triazole compounds. however there are three disadvantages, thefirst is the use of the homogeneous catalyst can make cuprous bromide havecertain residue in the product, The second is the reaction lasts for a long time,the third is the use of organic solvents causes a big pollution to theenvironment. Therefore, it is necessary to design a greener, more efficient,simple and reusable catalysts for catalytic azide and alkyne click reaction.This article mainly aims at the above three problems, using a simple chemicaland physical supported method for the preparation of heterogeneous catalysts,water as reaction medium, using microwave radiation to promote the reaction,and use “one pot” method synthesis strategy, also studied the application ofthis method in the synthesis of dendrimer. The main work of this thesis can besummarized as follows:The first chapter mainly describes the click chemistry classes and various kindsof supported catalyst for catalytic CuAAC, introduces the methods ofmulticomponents reaction and the research background and main content.The second chapter using the Fe3O4/GO as catalyst carrier, water as reactionmedium, three components “one pot” synthesis of single and double instead oftriazole compounds. The characterization of the catalyst by TGA, XRD, FT-IR, AAS,results proved that the catalytic’s physical and chemical properties are stable,separated easy, can be recycled up to6times. Scale-up synthesise1-benzyl-hydrogen-phenyl-1-1,2,3,4-triazole.The third chapter using fishbone, get fine powder by grinding, through physics absorption and ion exchange on the principle of load catalyst cuprous bromide, undermicrowave radiation heating conditions and catalytic synthesis containing triazolepotentially bioactive molecules in aqueous solution. Expect to large-scale to usewaste.The fourth chapter using silica gel and ligand load copper as catalysts, threecompounds “one pot” to synthesis dendrimer, the dendrimer molecular’s structure isperfect.The five chapter of this research are summarized and prospected for the future ofthe work.