Study On The Nucleophilic Ring-opening Reacitons Of Aziridlnes

In this thesis, the ring-opening reactions of aziridines under green conditions weredescribed.In part one, the ring-opening reaction of aziridines with alkyl halides and thioureain green solvent of PEG-200-H2O was studied in detail. The results indicated that thereaction between thiourea and the alkyl halide in situ form the sulfur anionintermediate, which attacks the aziridines afford the corresponding β-amino sulfidesin good to excellent yields.In part two, the ring-opening reaction of aziridines with alkynals was studied indetail. The results indicated that the reactions between alkynals and aziridinescatalyzed with N-heterocyclic carbine IXy.HCl gave the correspondingβ-sulfonylamino propynoic esters.