Synthesis Of N,N-Dialkylaminoacid Betulin Easter

Triterpene compounds widely exist in nature, the highest content of which is betulin, as much as34%in birch. Betulin is not only a bargain to extracted from accessible raw materials, but also has good pharmacological acitivities. So got the attention of the experts and scholars from domestic and abroad.Betulin and its derivatives, as biological agents, show a huge potential to be applied to the treatment of HIV, tumor and anticancer, exhibit the different mechanism of action from drugs in the past, have certain selective cytotoxicity to tumor cells. Because of the low-toxic or non-toxic, the derivatives from betulin have vast research prospects as an important drug intermediates and potential candidates for new drugs.Fifteen new betulin derivatives were synthesized, by acylation reaction of C-3and C-28of betulin with chloroacetyl chloride respectively or simultaneously, finally the amination with dialkyl amines accordingly, looking forward to improve the solubility in water and biological activity of betulin derivatives. The structures of these compounds were confirmed by means of FT-IR spectrum,’H-NMR, and13C-NMR.