Function Of Pou6F1in The Development Of Cortical Neurons

According to the POU proteins expression form and past evidence suggests that POU family proteins play an important function in embryonic development, particularly the early development and cell differentiation.Brn-5by pou6fl genetic encoding, is the first class VI, POU proteins expressed in nervous system widely, but specific expression in the epithelial cells of the fourth floor, we hypothesized that pou6fl in cortex cells plays an important role in the development, the current evidence shows that in the central nervous system development process, In the developing CNS its expression occurs in postmitotic neurons but not in proliferating neuronal progenitors. Experiments in the developing retina suggest that expression of Brn-5occurs24-48hours after progenitors exit the cell cycle., but about pou6fl knockout phenotype has not been reported,In this study, we used a detailed study of morphological means pou6fl on cortical cell development, and found pou6fl cells in the cortex was knocked out well, with family genes in cortical cells and no compensatory increase in using in situ hybridization to detect cortical developmental gene knockout mice in pou6fl the cerebral cortex, and to verify the pou6fl is proliferation, inhibiting differentiation genes...