Ultrasound In The Diagnosis Of Abnormal Fetal Aneuploidy Value

Objective To investigate the clinical application of prenatal ultrasonography inscreening chromosomal aneuploidy abnormalities(trisomy21, trisomy18, trisomy13,Turner syndrome).Methods Ultrasound screening had been performed on fetuses of trisomy21,trisomy18, trisomy13and Turner syndrome. Those fetuses were diagnosed byamniocentesis or cordocentesis. Ultrasound imaging features were compared withdifferent chromosomal aneuploidy fetuses. Analysing the function of NF in screeningchromosomal aneuploidy fetuses. The typical ultrasound findings as trisomy18wereevaluated. Also of trisomy13and Turner syndrome.Results (1)The chromosome karyotype anaylsis of the pregnant women whounderwent amniocentesis or cordocentesis showed that there were14fetuses withNF thickening. Trisomy21was found in4fetuses among them. The detection ratewas28.57%. There were60fetuses with other abnormalities. Trisomy21was foundin3fetuses among them. The detection rate was5.00%. The detection rate of trisomy21detected hinted by fetal NF thickening was higher than that of other abnormalultrasonic manifestations(P=0.015).(2)The typical ultrasonographic abnormalities oftrisomy18in this study were cardiac anomalies, foot or hand anomalies,strawberry-shaped skull and choroid plexus cyst.(3)Five fetuses of trisomy13underwent ultrasound screening all had at least two abnormal sonographicfindings.Cardiac anomalies was the most common findings. Other commonsonographic findings included holoprosencephaly, craniofacial malformations andpolydactyly.(4)The most typical ultrasonographic abnormalities of45,X in this studywas fetal nuchal cystic hygroma. The detection rate was100%.Conclusion As a non-invasive technology, ultrasonography plays an important role in screening chromosomal aneuploidy abnormalities.