| Objective:To observe the clinical efficacy and influence of Miao medicine tongqiaohuashuan on plasma levels of t-PA、 D-dimer in patients with acute cerebral infarction,the and primarily explore its mechanism relating to regulating fibrinolytic system.2、 Methods:1、 Group:60patients with cerebral infarction, according with the inclusion criteria (wind-phlegm stagnation) were randomly divided into two groups:treatment group and control group with30patients repectively.The control group was treated with Changchunxiting Injection and aspirin, on the base of it, treatment group therapy was added with Tongqiaohuashuan Decoction.The course was The course was14days.2、 Treatment method:The control group was given Changchunxiting Injection (60ml/d). Treatment group therapy was added with Tongqiaohuashuan Decoction(100ml tid).Both groups were treated with aspirin.The course was14days.The NIHSS、 ADL scores and TCM clinical effects of two groups were judged to observe clinical efficacy.Levels of t-PA、 D-dimer before and after treatment were compared to explore its proper mechanism. The safety issue of drugs were observed meanwhile.Results1.Clinical results:The NIHSS、 BI scores of two groups after treatment were obviously improved compared with that of groups before treatment, the improvements were not significant between the two groups(p>0.05).Scores of NIHSS tended to decline and scores of BI tended to increase compared with that of control group.Comparison of clinical efficacy of traditional Chinese medicine indicated that: In the treatment group3cases of recovery,10cases of significant validity,7cases of validity,8cases of a little progress and2cases of invalidity, the total effective rate is93.33%;In the control group,1case of recovery,6cases of significant validity,8cases of validity7cases of a little progress and8cases of invalidity, the total effective rate is73.33%.Clinical efficacy of TCM in the treatment group is better than that in the control group (P<0.05) after statistical analysis,which indicated that Tongqiaohuashuan Decoction could improve symptoms of acute cerebral infarction.2、 Differences of t-PA、 D-dimer levels before and after treatment between two groups were significant(P<0.01), and changes of t-PA、 D-dimer levels in treatment group were also obvious compared with that of the control group(P<0.05).Conclusion:1、 Clinical efficacy of treatment group was better than that of the control group in treating ACI patients (wind-phlegm stagnation), treatment group could have better effect on ACI patients (wind-phlegm stagnation)。2、 Treatment group could effectivly inhance the activity of fibrinolytic system and decrease levels of D-dimer eventually,which could have effects of defibrase and thrombolysis. |
PDF Full Text Request