Lipoprotein Associated Phospholipase A2 Correlation Studies With Essential Hypertension And Metabolic Syndrome

Objective To explore the association of serum Lp-PLA2levels with essentialhypertension and metabolic syndrome.Methods Ninety cases of EH patients were selected as study group, and they weredivided into three groups: Group I with isolated hypertension of class I(n=30),GroupII with isolated hypertension of class II or more (n=30),and Group III withhypertension of class II or more and coronary heart disease (n=30). The control groupconsisted of30healthy persons selected randomly from the outpatient department.30patients with metabolic syndrome were selected from the90EH patients. Theconcentration of serum Lp-PLA2was measured using Enzyme-linkedImmunoabsorbent assay(ELISA).The fasting blood lipids, uric acid, glucose and otherbiochemical markers were detected with standard biochemical methods and werecompared among study groups.Results①The serum Lp-PLA2levels were significantly higher in Group I、GroupII and Group III as compared with control group. The difference was highlystatistically significant with p-values as P<0.01， P<0.01， P<0.01respectivelycompared with healthy controls.②The serum Lp-PLA2levels in Group III weresignificantly higher than Group II and the difference was statistically significant（P<0.05）.③StatisticalAnalysis showed positive correlation between serum levels ofLp-PLA2and SBP and DBP（r=0.644，P<0.01；r=0.431, P<0.01）.④There was alsoa positive correlation between serum Lp-PLA2levels and LDL-C （r=0.441,P<0.01）.⑤The serum levels of Lp-PLA2in patients with hypertension and MS weresignificantly higher than the control group（P<0.01）.Conclusion①The serum levels of Lp-PLA2were positively correlated withelevated blood pressure levels, and the levels were much higher in HypertensiveCHD patients than those with isolated high blood pressure, which shows that theLp-PLA2may be involved in the occurrence and development of hypertension.②The serum levels of Lp-PLA2in MS patients were significantly higher than thecontrol group and it may be involved in the occurrence of MS.