Biodegradable Material Poly (butyl Diacid Butyl Glycol Ester Performance Of Biomedical Research

Poly(butylene succinate)(PBS), as a fully biodegradable aliphatic polymer, has been successfully developed recently. Succinic acid, the degradation product of PBS, is just the intermediate product of Kreb’s cycle, which becomes the theoretical springboard of PBS’s usage in biomedical materials. At present PBS, as a environment friendly biodegradable material, has some advantages such as definite degradation, excellent mechanical performance, easy fabrication, et al. However, for PBS’s being the biomedical material, there are some strict requirement in biological safety aspect, and something like whether or not PBS is irritative and hypersensitive in the body, what about the blood compatibility of PBS, the degradation behavior of PBS are also indispensable.Based on the previous researchs of our research group, we manufactured and purified PBS with improved properties. Besides, we researched the irritation, delayed hypersensitivity and blood compatibility of PBS. Furthermore, the degradation behavior of both pure PBS and PBS/PLA blends in simulated physical environment were researched. The conclusions are showed as follows:1. The purification process didn’t influence the properties of PBS, and instead the structure characteristics and mechanical properties all demonstrated excellent properties of PBS;2. PBS induced no irritation and delayed hypersensitivity. The hemolysis rate and platelet adhesiveness showed good hemocompatibility of PBS;3. PBS definitely degraded in simulated physiological conditions, and the degradation mechanism was bulk degradation. And due to auto-acceleration effect, degradation rate experienced a slow-to-fast transition. When the number-average molecular weight of PBS was close to4×104, the transition occurred. The amorphous region of PBS first degraded and soon afterward the crystalline region.4. The incorporation of PLA effectively enhanced the tensile strength of PBS. And the binary system was proved to be immiscible, and sea-island was presented. The interface between each components facilitated the water infusion and degradation products release, thus leaded to the faster degradation in initial phase. With the proceeding of degradation, the carboxyl group gradually increased to some extent, then the mutual acceleration effect happened.