Temporal Lobe Epilepsy Animal Large-scale Electrophysiological Brain Network Research

Temporal lobe epilepsy (TLE), a common brain disease in clinical, threat oursociety and normal life to a farely large extent. As more evidences that many regions areinvolved in the process of epilepsy resembled, introducing the brainweb method that hasbeen common used in the area of neuroscience is benificial to deeply understand thegeneration and propagation of epilepsy. With the multichannel singnals collected fromrat model of TLE, We analysis the dynamic alteration of brainweb during epilepticprocess in term of network and pair relations of hub regions.There are several light points in our work:1. The issue of incorrect location of real souces caused by volume conduction inscalp electroencephalogram can be solved by interictal electroencephalogram recordingon live animals.2. Computing network measures directly on the weighted matrix without aartifical threshold enable us to make use of the full information contained in matrix.Besides that, we work on the alteration from single region level to network to gain athorough understanding of seizure.3. The comprehensive research of brainweb alteration under different EEGrhythm set us a deeper understanding of underline mechanism of seizure.In our work, we have these changes of rat brainweb during epileptic process:1. Analysis of brain synchronization under wide band (1-70Hz) shows that thisindex increase significantly after the injecting of pilocarpine while it drop dramaticlyduring preictal state. After that, the brain reach a higher synchronization level whenseizure occurs. A more deeply analysize demonstrate that alterations of brain under thetaand alpha rhythm consist with that of wide band. On contrast, alterations of brain underbeta band witness a reversed model.2. Network parameter analysis based on graphic theory demonstrate that the brainnetwork under theta band shift to order network after the injecting of pilocarpinefollowed with a opposite change in preicatal state. During the icatal state, the brainwebreshife to order network from random network. We found the same changes in brain network under alpha band while the brainweb alterations under beta rhythm show acontary way.3. Results of the mutual correlations of hub regions indicate that the relationbetween hippocampus and and thalamus is different from that of others. What’s more, Itshould be noticed that the variations of correlationship betwween anterior cingulatecortex these tworegions (hippocampus and thalamus) are in accordence with synchronyalterations of brain.As all these results considered, we can conclud that different EEG rhythm play adifferent role in epileptic precess. Disturbances of brainweb under theta and alpha bandis crucial for epileptogenesis while brain network under beta band may support asadditional path for normal brain functional interaction during this process. Besides that,the correlationships among hippocampus and and thalamus and anterior cingulate cortexare quite important for propagation of epilepsy.