Introducing Concept Of Pro Make Old Age Research Of Clinical Diagnosis Of Dementia Rating Scale

Objective:1. To make a initial PRO rating scale of senile dementia, which provides a new and convenient way for clinical diagnosis grading of senile dementia.2. Introducing the concept of PRO to provide basis for TCM treatment quantification research of senile dementia.Methods:Combined with international diagnostic criteria to collect60elder patients met the inclusion criteria. Then evaluated them by A/B paper, and sorted them by international approved scales, MMSE, MoCA and CDR, into three groups: MCI group (21cases), mild dementia group (24cases), moderate and severe dementia group (15cases). Verified the reliability, validity and discrimination of the PRO rating scale of senile dementia(A/B paper), and established a discriminant function model by multiple discriminant analysis, initially developed a clinical diagnosis of grading criteria for senile dement ia.Results:Thi s research has collected60cases, including25males and35females, the average age is72.05years. They were divided into three groups. MCI group21cases (35.0%), mild dementia group24cases (40.0%), moderate and severe dementia group15cases (25.0%).1. Reliability testThe Cronbach’s alpha of Paper A is0.789, and Paper B is0.908, which indicate two papers’good inner consisitency. Split-half reliability shows A/B paper, the volume is split in two parts with a good correlation.2. Validity testAs this PRO rating scale (A/B paper) is finally established through literature survey, scientific discussion and professional demonstration, it can be considered has high content validity. The criterion-related validity test has proved the score of A/B paper has a high linear correlation with MMSE, MoCA and CDR, which indicated good criterion-related validity. Adopting principal component analysis to extract common factor, we get initial load matrix, according to characteristic root extract top three common factor, it explains46.373%of total variance in Paper A and73.565%in Paper B. After varimax we get rotated component matrix, indicates that Paper B has good contact validity. Because of Paper A is a self-identification system and patients with cognitive impairment have inaccurate judgment on their condition, the common factors on Paper A with a Low explanatory power, but the result of factor analysis is acceptable with the expected design, we will expand the sample to make an further val ida t ion.3. Discrimination testThe Kruskal-Wallis test of Paper A and Paper B shows p<0.01, indicated that each paper of three groups has significant difference, and A/B paper with a good discrimination.4. Response rate testWe observed the positive response rate of each item in A/B paper, it turned out that item a21in Paper A has a low grade, and Paper B of a higher overall response rate than Paper A.5. Discriminant analysisAs the score of Paper A and Paper B to be a discriminant index variable, and the group to be a Categorical variable, we established a discriminant function model by multiple discriminant analysis. The accuracy is82.6%, and of each group is84.6%,78.3%,90.0%.Conclusion:1. The PRO rating scale for senile dementia has good reliability, validity and discrimination.2. The discriminant function model established by the score of Paper A and Paper B can initally discriminate the cognitive impairment elder patients’cognitive function,and has good accuracy.3. With further work, this PRO rating scale can be used as a clinical diagnosis grading means of senile dementia, and will provide a new basis for TCM treatment quantification research of senile dementia.