| Purpose:Chinese medicine is based on the rich clinical experience. Different doctors of Chinese Medicine would use different herbs on the same disease. So use a scientific way to analyze the method of using the herbs, even find some new prescriptions bases on the methods to guide clinical treatment.To analyze the principles of prescriptions for chronic heart failure patients by using data mining technology based on traditional Chinese Medicine Inheritance System.Methods:The retrospective analysis of the prescriptions for272chronic heart failure patients of China-Japan Friendship Hospital between Jan.2006and Dec.2011, who had been treated by traditional Chinese medicine, For the first time after all the prescriptions in hospital, ruled out with a lung, liver, kidney and hematopoietic system of primary diseases such as serious patients, by using the data mining methods, such as revised mutual information, complex system entropy cluster and unsupervised hierarchical clustering, etc. It is expected to find the relationship of the different herbs, drug collocation and core combinations.Results:78kinds of herbs are used frequently in clinical Found that one of the most commonly used classes of drugs to fill empty medicine, a total of13820times the use, well ahead of other drugs, including fill gas drug use9600times, times of commonly used for activating blood circulation and eliminating stasis drugs use of seven kinds of334times. And32drug collocation correlative coefficients are more than0.02.Such as benefit spirit, rose trapped medicine astragalus, tangshen, cohosh, with turmeric, nut, radix3arris, sprouting, such as CheQianZi compatibility, cohosh and balloonflower, with the Yu altogether meat, shows the function such as red flowers and similar drugs with cooperation.46core combinations and13new prescriptions were mined from the database. From the core drugs and provides can see, ShengMaiYin, TingLi jujube xie lung soup, ephedra aconiti asarum soup, small trapped chest soup, melon soup Xie trichosanthis sprouting white diarrhea lung qi and the water, rubbing the kidney, eliminating phlegm heart diarrhea turbidity classic formulas is clinical treatment of chronic heart failure core. Core combination and new prescriptions for clinical or foundation provides useful clues, we will through the clinical and experimental research further discuss the curative effect and the function mechanism.Conclusion:With the help of Traditional Chinese Medicine Inheritance System on administration and analysis the principles of the different herbs, drug collocation and core combinations in the collected prescriptions and it has important significance for creating new prescriptions. Based on frequency statistics, improved mutual information method, complex system entropy clustering, no supervision of entropy clustering level without supervision and data mining methods of traditional Chinese medicine of inheritance system deal with the conclusion and clinical experience basic consistent, and more intuitive reflects the chronic heart failure of herbal rule, prove the data mining technology in the field of TCM prescriptions summary law plays an important role. |
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