Kidney And Pulse Treatment The Clinical Curative Effect Of Elderly Isolated Systolic Hypertension Research

Object:To discuss the curative effects, improvement of quality of life and security of Bushen Hemai Prescription in treating Elderly Isolated Systolic Hypertension (EISH) with standardized antihypertensive drugs. To create the new therapy called Bushen Hemai. As a clinical evidence in treating EISH, protecting target organs, reducing the complications and the incidence and mortality of cardiovascular and cerebral event, this research attribute to evaluate and study Combination intervention plan.Methods:This subject adopts a double-blind randomized controlled clinical study with the Method of delamination and region group. There’re65patients involved in grade1or2of EISH, aged60-79years old. Test group assumes the treatment scheme of Chinese formulas and standardized antihypertensive drugs, while placebo and standardized antihypertensive drugs was chosen for control group. The research is divided into two stages:lead in period and random-treatment period. Lead in period lasts for two weeks:Patients who only take one kind of antihypertensive drugs in late4weeks should process this period, while who never take any kind in late4weeks can pass this period. Random-treatment period lasts for12weeks:CCB (Felodipine Sustained Release Tablets,5mg Po Qd) was given to both two groups as basic antihypertensive treatment. According to the different symptoms, patients are divided into different syndromes and given Chinese formulas and placebo avoiding decocted granule. Follow up clinic every2weeks, deliver drugs, take BP3times and then record in the CRF. All the65subjects should have the tests before and after treatment such as CBP (SBP,DBP,PP)24hABPM(24hSBP,24hDBP,24hPP,24hSBP-L,24hDBP-L,etc),the evaluation of the life quality(WHOQOL-BREF, etc)and laboratory safety index(Blood routine and Blood Biochemistry). Calculate the effective rate and the proportion of patients reaching BP target according to the decreasing range of24hSBP. Reach BP target:24hSBP<140mmHg after treatment. Decrease BP efficiently:the decreasing range of24hSBP>10mmHg after treatment. Unblinding and statistical analysis will process after finishing the whole study and tests. Results:After the treatment of12weeks, the BP of test group and control group was both effectively controlled and steadily decreased. As to the decreased BP effective rate of test group (94.3%) and control group (87.5%), there are no significant difference (x2=1.119, P>0.05). The contrast of the proportion of patients reaching BP target between test group(88.6%) and control group(80%) shows apparent difference (x2=17.515, P<0.01). In the aspect of the decreasing range of PP, there exists remarkable difference between the two group (t=3.248, P<0.01).No changes occurred on Heart Rates of control and test group after treatment (P>0.05). These two groups can both obviously improve the quality of life of patients. It shows better effect in test group than that in control group on improving the symptoms such as dizzy, frequency of urination at night and dry eyes. There was no occurrence of cardiovascular and cerebral events and adverse effects such as dizzy, hypersomnia, palpitation and edema during the treatment process. Laboratory tests show no significant differences (P>0.05) after the subject.Conclusion:1.The results show that flexible and alterable Bushen Hemai Prescription has remarkable effects on reducing SBP and PP without low DBP for grade1and grade2EISH patients with standardized antihypertensive drugs. It reduces the blood pressure effectively, steadily and continuously, significantly better than control group.2. The treatment of Chinese formulas with standardized antihypertensive drugs can obviously improve the quality of life of patients. It shows better effect than that in control group on improving the symptoms such as dizzy, frequency of urination at night and dry eyes.3.It can be used as priority chosen drugs and combination intervention plan of clinical antihypertensive treatment because of good safety and resistance of drug without occurrence of untoward reaction.