The Development Of Wound Wet Analgesic Gel Preparation And Evaluation

1The study of pharmaceutic adjuvant of cataplasm1.1The study of Polyacrylic acid synthesis process With reference to the literature of the report,the intermittent water solution polymerization process was used to synthetize the viscosity average molecular weight of Polyacrylic acid in the level of millions,studying the drug loadings and drug release.Finally we screened out the synthetic process of polyacrylic acid which could meet the characteristics of big drug loadings of the Traditional Chinese medicine.1.2The study of quality standards of pharmaceutic adjuvant of cataplasma The experiment takes the research of testing samples about appearance. content of each monomer, solid content. viscosity.Ph and density as the monitoring indexes to develop the quality standards of pharmaceutic adjuvant in order to make materials quality controllable.2The study of blank prescriptionTaking the temperciance and shapability as assessment indicators,through the orthogonal test,we studied the content of framework material, cross-linking agent, humectants. filler and the influence of different cross-linking agent to preparations in order to screen out the suitable type and dosage of cross-linking agent.3The study of Shangshizhitong Cataplasm3.1Liquid extract provided by QiZheng pharmaceutical. We sceen out the prescription process by taking the temperciance and percutaneous rate as assessment indicators. Pharmaceutical Technology3.2Quality standards:Determination of Atropine in Shangshizhitong Cataplasm by HPLC, drug release and Temperciance3.3Pilot scale experiments:we study the four kinds of cross-linking agent in order to resolve the problem of discontinuous production in industry3.4Stability tests:The room temperature test and accelerated test.