The Preparation Of Targeting Drug Carrier Material And Its Research

With the improvement of people’s living standard and pollution of environment, thecardiovascular disease and cancer has gradually become two major threats to health ofhumans. People found that it is difficult to cure disease by the traditional drugs, such as: poorefficacy, side effects and so on. While these problems can be solved well by targeted drugs.And drugs can be taken to lesions directly in a variety of forms and means by targeted drugs.And targeted drugs can enhance the therapeutic effects of drugs, while it can not damage othernormal organs and cells. The aspirin/chitosan magnetic microspheres and folate-conjugatedO-carboxymethyl chitosan were prepared and they can treat cardiovascular disease and cancereffectly.（1） Fe₃O₄nanoparticles were prepared by coprecipitation method, and SrFe₁₂O₁₉nanoparticles were prepared by sol-gel method. The magnetic strength of nanoparticles werestrength, and size of particles were very tiny.（2） The blank chitosan microspheres were prepared by microemulsion method, Theoptimal conditions was proved that: t（time of stiring）=60min, T（temperature of stiring）=60℃,n（speed of stiring）=2000r/min. The Fe₃O₄-chitosan microspheres and SrFe₁₂O₁₉-chitosanmicrospheres were prepared. And particles were charactered. The result showedSrFe₁₂O₁₉-chitosan microspheres were better than Fe₃O₄-chitosan microspheres in size andmagnetic.（3） The optimal ratio of strontium ferrite and chitosan was1:1of SrFe₁₂O₁₉-chitosanmicrospheres. And the aspirin/SrFe₁₂O₁₉-chitosan microspheres were prepared by aspirin,SrFe₁₂O₁₉and chitosan. The optimal ratio of aspirin, SrFe₁₂O₁₉and chitosan was3:2:2. Itsdrug loading was18.42%, and its encapsulation efficiency was64.48%. Once more, therelease effect of aspirin-magnetic targeted drug microspheres was proved perfectly. All ofthese provided theoretical for targeted therapy of cardiovascular disease. （4） The folate-conjugated O-carboxymethyl chitosan was prepared to treat cancer. Themain steps were chitosan was carboxymethyled and then O-carboxymethyl chitosan wascoupled with folic acid. Results show that the O-carboxymethyl chitosan was solubled in theneutral and alkaline solutions well. And the amount of folic of product was17.8μg/mg.