BRCA1mRNA Expression In Relation To Prognostic Of Colorectal Cancer Patients Received The Standard First-line Chemotherapy

Objective Aim of this study was to investigate the correlation of themRNA expression levels of the breast cancer susceptibility gene1(BRCA1) withclinicopathological parameters in patients with colorectal cancer receiving thestandard first-line chemotherapy regimens as well as their clincal prognosticsignificance. Materials and Methods The relative mRNA expression of BRCA1informalin-fixed paraffin-embeded colorectal cancer tumor specimens was measuredusing quantitative reverse transcription polymerase chain reaction.And therelationship between BRCA1levels with clinicopathological parameters and survivalin colorectal cancer was studied.Result BRCA1expression was not related toclinicopathological parameters except lymphnode matastasis(P=0.008)and vesselinvasion（P=0.013）in colorectal cancer.Though from multivariate analysis, the time ofoverall survival in middle-high group of BRCA1mRNA expression was69.56months, low group was55.67months.BRCA1mRNA hypoexpression was asignificantly favorable factor for overall survival(p=0.039),not for time toprogression(p=0.93). From Cox proportional hazards model for survival,sex(P=0.023), stage(P＜0.001),intestinal obstruction or perforation as initialsymptom(P=0.046) were independent predictive markers of overall survival ofcolorectal cancer, years old(P=0.043), stage(P＜0.001), vessel invasion(P=0.002)were independent predictive markers of progression free survival.Conclusions It wassuggested that intratumoral BRCA1mRNA expression level maybe a predictive marker of survival of the standard first-line chemotherapy regimens in colorectalcancer.Sex, stage, intestinal obstruction or perforation as initial symptom,years old,vessel invasion were independent predictive markers of colorectal cancer. Objective Aim of this study was to investigate the correlation of themRNA expression levels of excision repair cross-complementing group1(ERCC1)with clinicopathological parameters in patients with colorectal cancer receiving thestandard first-line chemotherapy regimens as well as their clincal prognosticsignificance. Materials and Methods The relative mRNA expression of ERCC1informalin-fixed paraffin-embeded colorectal cancer tumor specimens was measuredusing quantitative reverse transcription polymerase chain reaction.And therelationship between ERCC1levels with clinicopathological parameters and survivalin colorectal cancer was studied. Result ERCC1expression was not related toclinicopathological parameters in colorectal cancer.Though from multivariate analysis,the time of overall survival in middle-high group of ERCC1mRNA expression was69.56months, low group was55.67months. ERCC1mRNA hypoexpression was asignificantly favorable factor for overall survival(p=0.049),not for time toprogression(p=0.575). From Cox proportional hazards model for survival,sex(P=0.023), stage(P＜0.001),intestinal obstruction or perforation as initialsymptom(P=0.046) were independent predictive markers of overall survival of colorectal cancer, years old(P=0.043), stage(P＜0.001), vessel invasion(P=0.002)were independent predictive markers of progression free survival. Conclusions It wassuggested that intratumoral ERCC1mRNA expression level maybe a predictivemarker of survival of the standard first-line chemotherapy regimens in colorectalcancer.Sex, stage, intestinal obstruction or perforation as initial symptom,years old,vessel invasion were independent predictive markers of colorectal cancer.