The Relationship Between Dexmedetomidine And BIS

Objective: Pumped the ICU recommended maintenance dose of0.2-0.7μg/（kg h） of the dexmedetomidine to the spinal-epidural anesthesiapatients, monitor the beginning to the end of surgery patients from bispectralindex （BIS） values, research the different doses of dexmedetomidine makepatients reach the sedative state ’s time, explore the relationship betweendexmedetomidine and BIS.Methods: Sixty patients who make spinal-epidural anesthesia, men37cases and women27cases ASA I or II, aged20-60, weighting50-90kg, nospirit, nervous system disease, no respiratory, circulatory system diseases,no narcotic drug allergy history,no long-term use analgesic and sedative drughistory，normal liver and kidney function and all patients with no preoperativeopioids.60patients wesearch the different doses of dexmedetomidine makepatients reach the the sedative state’s time whether different, explore therelationship between deere randomly divided into six groups, each group of10, each group represents different doses: D1(0.2μg/㎏^-1·h^-1)、D2(0.3μg/㎏^-1·h^-1)、D3(0.4μg/㎏^-1·h^-1)、D4(0.5μg/㎏^-1·h^-1)、D5(0.6μg/㎏^-1·h^-1)、D6(0.7μg/㎏^-1·h^-1). All patients stopped eating and drinking8^-12h beforeoperation．Coarser vein opened after the patient into the operating room andinfused Lactated Ringer’s and Hydroxyethyl starch solution with the rate of10^-12ml/（kg·h） to recover fluid balance. Patients take the right lateral tochoose L2-3clearance puncture and lumbar epidural anesthesia catheters3cmto the head-end. Were supine after the operation is successful, control ofanesthesia block level in the T6-8. Conventional oxygen mask oxygen flow6L/min.After that monitor BIS, Heart rate, blood pressure, ECG and SpO2.Dissolved dexmedetomidine200μg and saline48ml in50ml syringeconnected to a micro pump,6groups after anesthesia successfully before thestart of surgery respectively pumped the different doses of dexmedetomidine: 0.2μg/㎏^-1·h^-1、0.3μg/㎏^-1·h^-1、0.4μg/㎏^-1·h^-1、0.5μg/㎏^-1·h^-1、0.6μg/㎏^-1·h^-1、0.7μg/㎏^-1·h^-1，until the end of surgery. The other sedatives were not used insurgery. Records the BIS value began to pump the drug to the end of surgeryand recorded once every three minutes.Results:1Group of6patients with gender, age, body weight operationtine, the difference was not statistically significant.2Different doses ofdexmedetomidine make patients achieve sedation （BIS=65-85） the timerequired to differences （P <0.05）. D1, D2, D3, and D6are different. There isno statistically significant difference between the D4and D5, and the othergroup （P>0.05）. Between D1, D2and D3no statistically significant differenceeither （P>0.05）.3BIS values between dexmedetomidine given different dosesthere is a difference （P <0.05）. D1, D2, D3and D5, D6are different, betweenD1, D2and D3, the difference was not statistically significant （P>0.05）, nodifferent between D5and D6either （P>0.05）, D4with the rest of thedifferences between groups were not statistically significant. There is a goodlinear correlation between dexmedetomidine given dose and BIS values, thecorrelation coefficient r=-0.839, linear regression equationy=101.023-29.839x.Conclusion: The time of patients achieved sedation is different which indifferent doses of dexmedetomidine set at the recommended dose range ofICU. Different doses of this dose range BIS values is different, between themThere is a very good negative linear correlation, the correlation coefficientr=-0.839, linear regression equation y=101.023-29.839x.