| BACKGROUND:Nucleotide-binding Oligomerization Domain1(NODI) and Nucleotide-binding Oligomerization Domain2(NOD2) and NOD-like Receptor Family, Pyrin Domain Containing3(NLRP3) are the important members of the intracellular pattern recognition receptors. NODI and NOD2can recognize and bind intracellular pathogens or specific pathogens products, and then mainly active NF-КB signal pathway and initiate inflammatory reaction; NLRP3inflammasomes are a class of protein complexes which are characterized by regulating the maturation of proinflammatory cytokines including interleukin-1β (IL-1β) and interleukin-18(IL-18) through activation of caspase-1. As part of the innate immune and stress defense system. NODI and NOD2and NLRP3inflammasomes are thought to participate in the occurence and progression of many diseases, such as type2diabetes, atherosclerosis and alzheimer’s disease. OBJECTIVE:Explore the role of NOD1and NOD2and NLRP3inflammasomes in pulmonary disease. METHODS:Consult about NODI and NOD2and NLRP3inflammatory inflammasomes the latest research of pulmonary diseases in Pubmed, and review the composition and the activation mechanism of NODI and NOD2and NLRP3inflammasomes and the role of NOD1and NOD2and NLRP3inflammasomes in the pathogenesis of pneumonia, tuberculosis, chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and acute lung injury. DESIGN:Review. CONCLUSION(S):As part of the innate immune and stress defense system, although NOD1and NOD2and NLRP3inflammasomes are thought to participate in many pulmonary infectious disease, plays an important role in non-infectious pulmonary disease such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and acute lung injury. Research the role of NOD1and NOD2and NLRP3inflammasomes in differrent pulmonary disease will improve the understanding of pathogenesis of various pulmonary diseases, and may provide new train of thought for diagnosis and treatment of pulmonary disease. |
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