The Relationship Of Serum Nse Level And Metabolic Tumor Volume Or Total Lesion Glycolysis As Determined By Fdg Pet In Patients With Recurrent Small Cell Lung Cancer

[Background]In spite of high response rates to chemotherapy, recurrences occur around95%of patients with small cell lung cancer especially in the first year. Total tumor burden is frequently related to prognosis and tumor response to therapy. Currently, tumor maximum diameter determined by CT or MRI was widely used in clinical, but it has many disadvantages because the tumor shape is frequently irregular and it is hard to (?) distinguish tumor from necrotic tissue. FDG PET can overcome these disadvantages.[Objectives]The aim of the present study was to investigate the serum neuron-specific enolase(NSE) level in relation to the metabolic tumor volume(MTV) or total lesion glycolysis(TLG) by FDG PET in patients with recurrent small cell lung cancer.[Methods]Linear associations was found between serum NSE level and MTV or TLG (P<0.001). Pearson correlation analyses showed strong correlation between NSE level and MTV or TLG (r=0.787, P<0.001and r=0.866, P<0.001, respectively). However, we found no such linear associations and correlation between CEA level and Cyfra211level with MTV or TLG. In patients with normal NSE level, no correlation was found between NSE with MTV or TLG (r=0.018, P=0.958and r=-0.003, P=0.92, respectively), but the correlation was significant in patients with abnormal NSE level (r=0.789, P<0.01and r=0,872, P=0.01, respectively).[Results]MTV or TLG of recurrent SCLC measured by FDG PET have linear correlation between serum NSE level, and TLG show greater correlation coefficient. In patients with abnormal NSE level, higher NSE level indicate greater MTV and TLG TLG and MTV may serve as sensitive marker of tumor burden in patients with recurrent small cell lung cancer.[Conclusions]MTV or TLG of recurrent SCLC measured by FDG PET have linear correlation between serum NSE level, and TLG show greater correlation coefficient. In patients with abnormal NSE level, higher NSE level indicate greater MTV and TLG TLG and MTV may serve as sensitive marker of tumor burden in patients with recurrent small cell lung cancer.