| Objective:To evaluate plasma NT-proBNP levels in patients with stable angina unstable angina or acute myocardial infarction, and to investigate the relationship between the NT-proBNP levels and the severity and extent of involved coronary vessels.Objects and Methods:82patients with coronary heart disease patients enrolled in this study. According to clinical manifestation, electrocardiography and the levels of biochemical markers of myocardial necrosis, they were classified into3groups: stable angina group(SA, n=23), unstable angina group(UA, n=28)and acute myocardial infarction group(AMI, n=31).82subjects who underwent coronary angiography and calculated Gensini score. We compared these groups with20cases gender-matched cases who complained of chest pain and with negative CAG result. CAS group was divided into single-vessel(n=22), double-vessel(n=31)and triple-vessel group(n=29). Group n=8cases, the circumflex branch of anterior descending artery lesions n=5cases of the disease Group and the group n=8cases of right coronary artery lesions. Coronary angiography and good leave from the peripheral venous blood samples before analysis of the enzyme-linked immunosorbent assay method for the determination of plasma levels of NT-proBNP. All data processing were done using SPSS17.0statistical package. Measurement data expressed using mean±standard deviation, the two groups were compared using the t-test, multi-group comparison done using analysis of variance. Gensini and NT-proBNP level score, the level of cTnI and TIMI bleeding score between relevant inspection, Analysis of Selecting Spearman correlation coefficient. P<0.05differences have a significant mean.Results:1. The level of NT-proBNP was significantly higher in AMI groups than in other three groups(P<0.05), and was marked higher in UA than in SA Por control(P<0.05), also was higher in SA than in control groups(P<0.05).2. Among patients AHD, plasma NT-proBNP concentrations in patients with three-vessel was higher than those of patients with two-vessel and single vessle, P<0.05. P<0.01.3. In AMI group had a significant correlation between the level of NT-proBNP and troponin I(cTnI)(r=0.895, p<0.01).4. Plasma NT-proBNP concentrations in patients with left anterior descending coronary artery(LAD) was higher than those of patients with right coronary artery(RCA) and left circumflex coronary artery (LCX). P<0.01.5. With the comparison and analysis between the level of NT-proBNP and Gensini Score (r=0.963, p<0.01), we found the level of NT-proBNP tended to increase with the aggravation of coronary artery stenosis. TIMI flow showed a signal ficant negative correlation with plasma NT-proBNP levels(r=-0.39, P<0.01).Conclusion:1. Plasma NT-proBNP significantly increased in patients with coronary heart disease, prompting level of plasma NT-proBNP can be used to predict the severity of myocardial ischemia.2. Support the greater the number of coronary artery lesion, vascular the more important crimes, the higher the level of plasma NT-proBNP, prompting level of plasma NT-proBNP can be used to predict the severity of coronary artery disease.3. NT-proBNP levels in patients with acute myocardial infarction associated with the level of cTnI clearly working, prompting level of plasma NT-proBNP as a severity prediction of myocardial ischemia.4. The level of plasma NT-proBNP and Gensini score is positive, and TIMI bleeding score is negative, the more obvious tips NT-proBNP rise, the more severe myocardial ischemia.5. The levels of Plasma NT-proBNP have some value on risk assessment in patients with coronary heart disease. |
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