Correlation Research On Plasma Homocysteine、Hydrogen Sulfide Level And Cerebral Circulation Dynamics In H Type Hypertension

Objective H type hypertension is one special type essential hypertension(EH), which is characterized by the increased level of plasma homocysteine(Hcy). The current study shows that75%of the patients with EH suffer from homocysteinemia in China. Maybe it is one reason that patients have the higher incidence of stroke compared with western. It can product cytotoxicity, oxidative stress and inflammatory reaction in Hcy metabolism. Also Hcy inhibits the formation of hydrogen sulfide(H2S) in vivo. Deficiency of folate, vitamin B12, metabolic gene and key enzyme can result in dis-equilibrium of Hey in EH. Increased level of Hcy can enhance the oxidation stress of low lipoprotein and promote mononuclear cell adhering to blood vessel wall. Excessive lipid deposition is more likely to cause atheromatous plaque formation. Diastolic function is diminished in vascular endothelium and it increases the risk of stroke. Physiological level of H2S contribute to scavenge oxygen free radicals, dilate the blood vessels and delay the atherosclerosis(AS) change caused by hypertension. H2S can protects brain cells away from oxidation caused by Hcy and ease cerebral ischemia in hypertension. It has significant effect on diagnosis, treatment and prognosis in monitoring cerebral circulation dynamics in H type hypertension.The purpose of the present study was to investigate association of plasma Hcy、H2S levels and cerebral circulation dynamics in patients with H type hypertension.Methods:The104patients as experiment groups were graded in two groups according to the level of homocysteine, H type hypertension group and hypertension group, while there were32in the normal control group. Specific protein instrument was used to measure the Hcy, while sulfur sensitive electrode for H2S and cerebral circulation dynamics detectorfor detected flow dynamics of intracranial blood vessels. Auto DELFIA measured folic acid and vitamin B12.Result:1. Compared with controls and hypertension group, plasma H2S、folic acid and vitamin B12level expressed significantly decrease in H type hypertension(P<0.05). Cerebral circulation dynamics parameters were remarkable anomalies(P<0.001).2. The correlation analysis shows that plasma Hcy level was positively correlated with H2S、folic acid and vitamin B12(P<0.05). Plasma I Icy level was significantly correlated with Vmean、Qmean、Rv、Zc and DR(P<0.05). H2S level was significantly correlated with Qmean and Rv(P<0.05).3. Stepwise multiple linear regression analysis revealed that a significant independent association of Qmean with increases in plasma Hcy level, as well as association of Rv with decreases in plasma H2S level. The increased plasma Hcy level in H type hypertension was an independent risk factor for cerebral blood flow, and the decreased plasma H2S level was an independent risk factor for the cerebral vascular resistance.Conclusion:1. The increased level of plasma Hcy is ralated to decreased plasma folic acid and vitamin B12The level of plasma H2S is effected by Hhcy.2. The plasma I Icy and H2S level affect brain vascular physiology function,which can cause brain hemodynamic changes in H type hypertension patients.3. Parameters of cerebral circulation dynamics were significant differences in experiment group. Monitoring of cerebral hemodynamics provides significant basis for early diagnosis of cerebrovascular disease.