The Application Of Coronary Atherosclerotic Plaques By Dual-source CT In Female Patients With Type2Diabetes Mellitus

Objective:1. To investigate the imaging features of coronaryatherosclerotic plaques in type2diabetic patients of women;2. To exploremultiple factors of women patients with coronary atherosclerosis by dualsource CT.methods: From May2010to January2013,122cases withcorresponding image quality were retrospectively analyzed with women bydual-source CT coronary angiography. Plaque type, its distribution, extensiveand morphology were determined for. Patients were divided into groupsaccording to the following criteria. By T2DM (YES or NO), Group YES76cases(60cases have plaques in total); Group NO46cases(35cases haveplaques in total). By history of diabetes was divided into two groups:GroupA(＜10years); Group B(≥10years). By HbA1C was divided into twogroups:Group A(＜7.0%); Group B(≥7.0%).Results:1. The BMI, TG, HDL-C, LDL-C, FPG and HbA1C betweenthe DM and NDM of women were analyzed for the difference, and statisticalresults showed that there were significant difference(P＜0.05)。2. The results suggested that: age, history of diabetes, duration ofhypertension and HbA1C was positively related to coronary atherosclerosis,HDL-C and coronary atherosclerosis was negatively correlated.3. The study subjects were divided into three parts due to duration ofdiabetes (NDM to1, diabetic patients with duration of diabetes less than10years to2, and duration of diabetes greater than or equal to10years were assigned to3). There were statistically significant differences of them ofGensini scoring of the impairment of coronary artery(P＜0.05).4. The study subjects were divided into three parts due to duration ofdiabetes (NDM to1, diabetic patients with HbA1C less than7.0%to2, andHbA1C greater than or equal to7.0%were assigned to3). There werestatistically significant differences of them of Gensini scoring of theimpairment of coronary artery(P＜0.05).5. Analysis the different properties, extensive, and the counts of lesionsvascular between the DM and non-DM groups. The results showed the therewas significant difference(P＜0.05).6. Analysis the different distribution and morphology between the DMand non-DM groups. The results showed the there was not difference.Conclusion: The dual-source CT coronary angiography found thatT2DM patients with women had more calcified plaques, followed by mixedand soft plaques; type I plagues were mainly DM ones; the DM ones also hadmore vascular lesions, and the LAD was most likely involved. Age, durationof diabetes, duration of hypertension, and HbA1C was the most important riskfor coronary atherosclerosis, and had a negative correlation with HDL-C. Thedegree of stenosis had a positive correlation with the duration of diabetes andHbA1C.