Retrospective Study Of Clinical Characteristics And Prognostic Factors In49Medulloblastoma Patients

Object: Identify the relationship between the medulloblastoma patients’clinic characteristics as well as treatment and their prognosis. Study factorsrelevant to prognosis to provide better thinking and method for clinicperformance.Method: Collect data of49medulloblastoma patients admitted and treat-ed in the Second Hospital of Hebei Medical University to conduct a systemreview. Of all the49cases,28are male and21are female. Ages of patientsrange from11months to61years old and the average age is24.1years.15patients are over18years old and34under, among which29are under14.The courses of the disease range from2days to6months. Patient’s age, sex,initial symptoms, complaint, physical examnation, imaging findings, resectionrange, postoperational complications and chemoradiotherapy conditions arerecorded in detail. Follow-up visit is performed to collect data of survival timeand progression free survival time. These data are analyzed by Kaplan-Meierand survival curves are painted. Log-Rand method is used to determined thesignificance of difference. Finally a COX regression by Forward: LR isperformed to detect clinic factors relevant to medulloblastoma patients’5-yearoverall survival rate and3-year progression free survival rate.Result:1Males have a5-year overall survival rate of42.0%±14.0%whilefemales have a45.9%±12.4%. Males have a3-year progression free survivalrate of26.5%±9.8%while females26.5%±9.8%. Both Ps’ values are below0.05and no significant difference could be concluded2Patients over18have a5-year overall survivial rate of71.2%±14.5%while patients no older than18have a30.8%±10.8%. P is below0.05, whichmakes significant difference. Patients over18have a3-year progression free survivial rate of27.1%±13%while patients no older than18have a5.8%±5.1%. P is over0.05, which makes no significant difference.3Patients with tumor in vermis cerebelli have a5-year overall survivialrate of32.9%±10.8%while patients with tumor in cerebellar hemisphere havea83.3%±15.2%. P is over0.05, which makes no significant difference.Patients with tumor in vermis cerebelli have a3-year progression freesurvivial rate of23.7%±7.4%while patients with tumor in cerebellarhemisphere have a68.6%±18.6%. P is below0.05, which makes significantdifference.4Patients with GTR(gross total resection) and patients with STR(subtotalresection) have a5-year overall survivial rate of52.8%±10.5%and0%separately and a3-year progression free survivial rate of12.5%±6.4%and0%separately. Both Ps are over0.05, which makes significant different.5Patients receiving chemoradiotherapy and those not have a-yearoverall survivial rate of55.1%±10.9%and0%separately and a3-yearprogression free survivial rate of29.0%±8.5%and0%separately. Both Ps areover0.05, which makes significant different.6In the aspect of multi-factor analysis, patients with STR or notreceiving chemoradiotherapy or with tumor in cerebellar hemisphere suffer ahigher risk of death and tumor recurrence.Conclusion: According to the result of single-factor and multi-factoranalysis, resection range and chemoradiotherapy are independent factorsinfluencing5-year over survival rate; tumor position, resection range andchemoradiotherapy are independent factors influencing3-year progressionfree survival rate.