Study On Oxidative Stress Levels Of Different Sex Mice By Sleep Deprivation

Objective To observe the difference of oxidative stress between male and female rats induced by72h sleep deprivation. Methods After both male and female KM mice were sleep deprived for72h, contents of superoxide dismutase (SOD), malondialdehydealdehyde (MDA) which come from blood, heart, and brain tissue were measured. Results Compared with the control group, the experimental group of males and females are decreased in SOD and increased in MDA. Compared between both sexes, the content of SOD decreased more in males than in females. The content of MDA increased more in males than in females and mortality higher in males is than in females. Conclusion Oxidative stress can be increased by72hours of sleep deprivation both in males and females mice. The female mice show more better performance than males in terms of resistance to oxidative stress caused by sleep deprivation.