The Relevance Of Platelet Parameters In Patients With Acute Coronary Syndrome

Backward:Acute coronary syndrome is a clinical syndrome due to coronary atherosclerotic plaque rupture and erosion, which in turn thrombosis, vasospasm and microvascular thrombosis of multiple factors led to the acute or subacute myocardial ischemia and hypoxia caused. It includes ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome in two categories. Non-ST-segment elevation acute coronary syndrome, including unstable angina and non-ST-segment elevation myocardial infarction, is one of the most common types of coronary heart disease in clinical.In China, the incidence of acute coronary syndrome was significantly increased year after year, and the early age of onset. In the past more than20years, the diagnosis and treatment of acute coronary syndrome has made great achievements, but still a threat to human physical and mental health of the major public health problems. The pathophysiological basis include unstable atherosclerotic plaques rupture, activation of platelet aggregation, thrombosis, and vascular spasm. Therefore, the aim of anti-platelet aggregation of acute coronary syndrome has certainly inhibit thrombosis aggravated or new thrombosis. However, indicators of clinical testing platelet function, platelet function parameters in the diagnosis of acute coronary syndrome, and specific measures of anti-platelet aggregation therapy continues to study and work in progress.Objective:To investigate whether platelet parameters (platelet count, mean platelet volume, platelet volume distribution width and platelet-large cell ratio) are associated with acute coronary syndrome (ACS) onset and severity. It may provide the basis for the early diagnosis and antiplatelet therapy of patients with acute coronary syndrome.Methods:A case-control study.136patients with acute coronary syndrome and60patients with non-cardiac chest pain were selected. Blood samples were drawn at admission in patients in the fasting state. Platelet parameters, platelet aggregation rate (PAgR), biochemical indexes and blood clotting tetrachoric were measured by standard methods. Specified equipment, professionals underwent coronary angiography and percutaneous coronary intervention for the patients with acute coronary syndrome.Results:The platelet count (PLT) was significantly lower in patients with acute coronary syndrome as compared with patients non-cardiac chest pain(P<0.05). In addition, patients with acute coronary syndrome had higher mean platelet volume (MPV)(P<0.05) and platelet-large cell ratio (P-LCR)(P<0.001) compared with patients non-cardiac chest pain. Platelet volume distribution width (PDW) was not related to ST-elevation myocardial infarction (STEMI),unstable angina/non-ST elevation myocardial infarction (UA/NSTEMI) and non-cardiac chest pain (P>0.05). There was no significant difference between the platelet parameters and the severity of acute coronary syndrome (P>0.05)Conclusions:Decreased platelet count, increased mean platelet volume and increased platelet-large cell ratio are closely related with acute coronary syndrome. Measurement of them may be of some benefit in detecting those patients whether higher risk for chest pain. Platelet parameters may be an important reference, especially in primary health care institutions. Platelet volume distribution width is no correlation between the incidence of acute coronary syndrome. Platelet parameters are no correlation with the severity of acute coronary syndrome.