| Chronic atrophic gastritis is the gastric mucosal epithelium and gland atrophy,accompanied by intestinal metaplasia and atypical hyperplasia of chronic disease. Ifchronic atrophic gastritis with intestinal metaplasia and gland hyperplasia, has thepossibility of canceration. At present, the average incidence of atrophic gastritis is ashigh as13.8%, its local characteristics is very obvious, in these areas prone to cancer ofthe stomach, bowel transformation of atrophic gastritis to gastric cancer has the highestincidence reached29.7%. Most researchers believe that environmental factors in theincidence of atrophic gastritis and gastric cancer plays a main role, including dietaryfactors (people like eating salted fish and pickled vegetables and seafood, etc.) areparticularly important.Research purposes: the zhoushan main island and daishan island residents in recentyears, gastric mucosa biopsy pathology analysis, summarized in patients with age, gender,degree of HP infection, intestinal disease characteristics, with hyperplasia, im looking forthe relationship of atrophic gastritis and gastric cancer. Simulated island characteristicdiet and dietary factors may induce gastric mucosal injury animal model was established,experimental gastric mucosal injury in mice by observing the different group, promptisland related diets cause gastric mucosal lesions or atrophic gastritis induced factors.Research method: divided into three steps: first, collect and organize island region’shospital patients with atrophic gastritis, gastric carcinoma in recent years the clinicalpathological data; Second, the experimental mice were divided into five groups, withfeeding method, respectively, to establish animal model of gastric mucosal injury toobserve different groups experiment degree of gastric mucosal injury in mice; Finally,screening of clinical pathology specimen, using immunohistochemical method indifferent age groups of intestinal type atrophic gastritis and part of the gastric mucosa inpatients with gastric cancer suppressor genes and molecular marker of pcna.1.Collect and organize island areas of hospital pathology in patients with atrophicgastritis and gastric carcinoma in recent years data:(1) summarize the zhoushan DingHaiOu four hospital in January2010-December2010, two years of gastroscopebiopsy specimens,4327cases of atrophic gastritis and543cases of gastric cancerpatients with gender, age, degree of HP infection, intestinal, with hyperplasia andhistological type of gastric carcinoma were compared with risk analysis;2) collect, sortout the daishan hospital during2006-2006within six years23114cases of gastric mucosawere analyzed,21254cases in21254cases of gastritis and gastric cancer patients withgender, age, degree of intestinal change, with hyperplasia and precancerous lesion andgastric cancer risk were analyzed.2.To establish animal model: island features diet, increase may lead to gastricmucosa damage of dietary factors to establish animal model, observation experiment inmice survival quality and the pathological changes of gastric mucosa damage, found theisland in the diet can lead to gastric mucosa disease or the onset of atrophic gastritisinduced factors.3.Screening specimen, using immunohistochemical method for department ofpathology, the first hospital of zhoushan30-60years old of different age groupsAtrophic gastritis in72cases,102cases of gastric cancer pathological specimens formolecular detection of tumor suppressor genes Runx3, conducted in102cases of gastriccancer specimens proliferation cell nuclear antigen of ki67molecular detection.Especially in cases with intestinal and hyperplasia of novel tumor suppressor RUNX3gene and nuclear proliferation ki67antigen of tracking detection, summarize the rule ofatrophic gastritis to gastric cancer, to find a solution to the islands district youth links andthe pathogenesis of gastric cancer.The results and main conclusions:1.①the pathological data of zhoushan island analysis shows: the incidence ofatrophic gastritis women more than men; Intestinal type atrophic gastritis onset age, inturn, to50group>60years old group>40years old; HP infection ratio1:2.6, the agecharacteristics of50years old group>30group>40years old; Atrophic gastritis withmild hyperplasia peak age for30to39years old, a high incidence of moderatehyperplasia ages50to59years old.②of daishan hospital23114cases of gastroscope pathological data analysis showed that a ratio of1:1in the pathogenesis of chronicgastritis, superficial gastritis,4820cases, chronic inflammation associated with intestinalmucosa in11570cases,4736cases of atrophic gastritis. Gastritis high age group, in turn,is41-60years old group>21-40years old group>61-80-year-old group>0-20-year-old group.486cases of gastric cancer, twice as many men as women come on; Highprevalence of41-60years of age. This data suggests that island residents of intestinaltype of gastritis and gastric cancer incidence in men may related to such factors as theenvironment and eating habits.2.Denominated in animal model studies show: five, according to the results of theexperiments island dietary factors related to the degree of the pathological changes ofgastric mucosal injury induced a heavier to light is in turn: metamorphic shrimp crabgroup> fish innards> fish bile pollution diet group, compared with those of other groupsof seafood food collocation grows the most healthy mice group, its ability to reproduce.Reasonable collocation and edible protein in a right way of seafood products, canenhance physical fitness.3.An immunohistochemical study of atrophic gastritis with all ages of mild,moderate, severe intestinal RUNX3expression, found that as the degree of bowel isaggravating, RUNX3loss of tumor suppressor genes, the more obvious; Moleculeexpression of pcna ki67reaction is closely related to cell cycle, in poorly differentiatedtumor tissues of ki67expression was much higher than good tumor tissue differentiation,prompt with the degree of malignant tumor and tumor invasion, metastasis andprognosis. |
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