Retrospective Investigation About Symptom And Outcome Of Hypernatremia In Severe Neurological Patients

Objective: Our study investigates the incidence,clinical features, risk factors andprognosis of the Patients with hypernatremia in the neurological intensive careunit(NICU), aiming to raise awareness of the Patients with hypernatremia and proverelevant preventive measures.Methods: Retrospective study method is used to investigate and observe the clinicinformation of200patients in NICU of our hospital from September1st,2011toJune1st,2012. Statistical analysis is conducted by SPSS for Windows Ver.19.0statistical software. Measurement data are expressed by x±se, and count data areexpressed by rate (%) and (or) constituent ratio (%).The association betweenHypernatremia and non-hypernatremia predisposing factors were assessed using χ2test, t test, rank-sum test and multi-factor non-conditional Logistic regression modelfor predictor identification.Results: General comparison of the two groups of patients, including age, sex,history of stroke (cerebral infarction, cerebral hemorrhage), hypertension, diabeticindicators showed no significant difference (P>0.05). Hypernatremia mortality rate(70.2%) was significantly higher than the non-high hypernatremia group (45.8%),hypernatremia group and non-high hypernatremia group on the prognosis of patientswith a significant difference (P <0.05).200cases of patients with different diseaseincidence of hypernatremia is divided into: cerebral hemorrhage was40.4%, cerebralinfarction31.9%, and21.3%of the intracranial infection, other6.4%, various typesof diseases difference was not statistically significant (P>0.05). With the serumsodium concentration increased, the mortality rate of patients gradually increased.Hypernatremia cases of four groups of varying degrees of mortality, thedifference was not statistically significant (P>0.05). The hypernatremia averagehospitalization time10.09±9.906days, the average length of stay ofnon-hypernatremia9.27±9.277days, hypernatremia group than the group ofnon-high hypernatremia hospital stay extended, the difference was not statisticallysignificant (P <0.05).Conclusions:Hypernatremia group mortality rate is higher than the mortality rate ofnon-high hypernatremia group, hypernatremia is an independent risk factor affectingthe prognosis of nerve in critically ill patients. The hypernatremia hospitalizationprolonged hospitalization than non-hypernatremia group. Hypernatremia mortalitygradually increased with the increase of serum sodium concentration.Hypernatremiaoccurred regardless of the type of illness. The use of large amounts of mannitol,mechanical ventilation and renal dysfunction is a the hypernatremia risk factors.