The Study Of The Relationship Between Fasting C-peptide Level And Coronary Heart Disease In Type2Diabetic Patients

Objective: To study the relationship between fasting C-peptide levels andcoronary heart disease in type2diabetic patients.Methods: Sixty-seven patients were selected randomly from thoseinpatients in the department of endocrinology of the Second Hospital of JilinUniversity since October2010to October2011. All the patients werediagnosed type2diabetes according to the American Diabetes Association(ADA) diagnostic criteria for diabetes in1997, excluding type1diabetes,gestational diabetes, other special type of diabetes, acute diabetic complicationssuch as hyperosmolar coma, lactic acidosis, diabetic ketoacidosis and thosewith tumors, liver or kidney failure and connective tissue diseases. Thediagnosis of coronary heart disease were made according to World HealthOrganization (WHO) diagnostic criteria for coronary heart disease, mainlydependent on the history of typical angina or cardiac distress, ECG changes inmyocardial ischemia or old myocardial infarction, or confirmed episodes ofST-T changes through treadmill exercise test or24-hour dynamicelectrocardiogram, or confirmed through coronary angiography. Generalclinical data were colleted including gender, ages, body weight (kg), height (m),BMI (kg/m2), duration of diabetes, smoking history, history of hypertension.Fasting C-peptide (FCP), triglyceride (TG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting plasm glucose(FPG) were all tested. All patients were divided into2groups: group1weretype2diabetic patients without coronary heart disease (n=42) and group2were type2diabetic patients with coronary heart disease (n=25). All measurementdata were expressed as as x±s and t test was made so as to compare thedifferences between the2groups. X2test was made in enumeration data. Allstatical analysis were carried out by SPSS13.0software package.Results:1)62.7%(42/67) of all type2diabetic patients were in group1and37.3%(25/67) were in group2. There were30male and12female patients in group1,while6male and19female in group2. There was significant difference in thegender composition of the two groups by X2test (p<0.05).33.3%(14/42)patients smoke in group1and60%(15/25) in group2. The rate of smokingwas different significantly between the two groups by X2test, too (p<0.05).There were45.2%(19/42) diabetic patients with concomitant hypertension ingroup1and88%(22/25) in group2. The rate of hypertension was significantlyhigher in group2than that in group1(p<0.05).2) Fasting C-peptide, fasting plasm glucose, total cholesterol, LDL-C andage in group2were significantly higher than those in group1(p<0.05).Conclusion:1) Fasting C-peptide can be used as a biomarker to monitor and predict therisk of the coronary heart disease in type2diabetic patients.2)The occurrences of coronary heart disease in type2diabetic patientswere associated with gender, smoking, hypertension, the levels of fastingC-peptide, fasting plasm glucose, total cholesterol and LDL-C.