Comparative Analysis Of The Clinical Features And Imaging For Patients With Vascular Parmnsonism And Parwnson’s Disease

Objective：To compare the differences of clinical features and imagingbetween vascular parkinsonism(VP) and Parkinson’s disease(PD).Improve the awareness of vascular Parkinson’s syndrome.Methods:Select65cases of VP patiens named VP group,and93cases ofPD patiens named PD group, Collected clinical data and imagingresults, Record the location and quantity of infarction lesions.Spss20.0software was applied for statistical analysis.Results:1、VP and PD groups have no difference in gender study,but theonset of age for VP group is71.3±8.1, is later than PD.Thereare more petiens with history of stroke、hypertension、diabetes、hyperlipaemia.There is no significant difference of heart diseasebetween the two groups.2、The main clinical manifestations of patients with VP werebradykinesia、rigidity、postural instability and gait difficultyand less static tremor.The parkinsonian features in VP have anundertone of upper motor neuron(UMN) or pyramidal signs. These manifest as spasticity, Pathological reflex, Tendonhyperreflexia, and hemiparesis or hemiparesthesia. The rigidityis greater in the lower extremities than in the upper,Cogwheeling,however, is quite rare in VP. Hypomnesis and count disturbanceof VP are more obvious than PD. Between the two groups,intentiontremor, start or stop difficulties, dysarthria, uracratia,emotionaldisorders showed no statistical difference.3. Two groups of patients, the VP group of single-shot cerebralinfarction has not been found;most of them were multiple lacunarinfarction,and all patients were found the presence of basalganglia infarct.The cerebral infarction size of34(52.3%)patients exceed the size of lacunar infarction.9(13.8%) patientshave massive cerebral infarct.There are6(9.2%) patients haveless than10infarct,but all of this6patients have massiveinfarct.28imaging of93PD patients were normal,and most of thepatients with cerebral infarction only has a small amount oflacunar infarction.4(4.3%) patients have massive infarct. Thereare13(14%) patients have more than10infarcts. In the analysisof cerebral infarction, the number of infarcts of VP group wassignificantly more than the PD group.4. All of the89patients with levodopa treatment in PD grouphave a good efficacy.There were31patients with levodopa treatment in VP group,26of them have efficacy.5of them have notherapeutic value.Conclusion:History of stroke,old age,hypertension,diabetes, hyperli-pidemia are the risk factors of VP. Besides tremor,VP patien-ts can be accompanied by other symptoms and signs of PD, andmany with the signs and symptoms of cerebral apoplexy. If thehead CT or MRI showed normal or only a small amount of infa-rct or asymptomatic cerebral infarction, support the diagnos-is of the PD; If more cerebral lesions were found and widelydistributed, and the number of lesions is more than10, most-ly in the basal ganglia or brainstem, support the diagnosisof VP.Part of the VP petients can get efficacy of therapeuticdoses,but inferior to idiopathic Parkinson’s disease.