Clinical Analysis Of28Patients With Motor Neuron Disease

Objective：To investigate the clinical characteristics and auxiliaryexamination of patients with motor neuron disease，to have a betterunderstand of it and to advance the diagnosis of it.Method：Retrospectively analyze of the clinical dates of28patientsdiagnosed with motor neuron disease in the neurology department in ourhospital，summarized of their gender，age，clinical features and laboratoryexaminations．Results：Of all the28patients, the age onset is23-77years，and theaverage age is（47.71±11.09）years. The upper limb onset in9cases(32.14％)，4of which gradually developed bulbar paralysis，and the he averagetime is11.6months. The lower limb onset is8cases(28.58％)，4of whichgradually developed bulbar paralysis，and the average time is6months,the other4patients didn’t show bulbar paralysis ever. The average timeis19months．9cases(32.14％) have both upper and lower limbssymptoms at the same time，and5of them gradually developed bulbarparalysis. The average time is10.4months.2patients(7.14％) have onsetof bulbar paralysis directly．Conclusion：The disease is chronic progressive disease，it’s moreseen in people of45ages. The average age is （47.71±11.09） years. Amyotrophic lateral sclerosis is the common hypotype. Muscle weaknessand/or muscle atrophy and pyramidal tract damage is the most2commonclinical manifestations．The most common seen is upper limb onset andupper-lower limbs onset，then the lower limbs onset, less seen is bulbarparalysis onset. Patients with upper onset or upper-lower onset aresusceptible to bulbar paralysis. Early misdiagnosis is cervical spondylosis,spinal cord disease and cerebrovascular disease. Electromyogramexamination is of great significance to the diagnosis of the disease, clinicaldiagnosis should be combined with the development process and auxiliaryexamination.