Study On Computed Tomography Perfusion Imaging Of Maxillofacial And Neck Normal Tissues And Squamous Cell Cancers In Head And Neck

Objective1.To measure the maximal slope of time-density curve(values of tan) of normal tissues(masticatory muscle, sternocleidomastoid, neck muscle, tongue, parotid gland, submandibular gland) in maxillofacial and neck, perfusion parameters, including blood flow(BF), blood volume(BV), mean transit time(MTT), and capillary permeability surface area product(PS), provides the foundation for studying CT perfusion in tumors of head and neck.2.To compare the differences of perfusion parameters between normal gland,submandibular gland,sternocleidomastoid muscle, masticatory muscle and the neck muscle in normal side and suffered side, to evaluate the influence of tumour on the perfusion parameters of adjacent normal tissues.3.To measure the CT perfusion parameters (BF、BV、PS、MTT) of squamous cell cancers in head and neck, and the maximal slope of time-density curve(TDC).4.To compare the differences of the same perfusion parameters between adjacent normal sternocleidomastoid muscle, masticatory muscle and the neck muscle tissues and squamous cell cancers in head and neck.5.To compare the differences of the same perfusion parameters between squamous cell cancers in head and neck and and normal tissues, among normal tissue with different degrees of differentiation.Materials and methods1.Eighty-one normal (including thirty-six disease affected areas of thirty squamous cell cancers in head and neck) tissues in maxillofacial and neck diseases(tongue, parotid gland, submandibular gland, masticatory muscle, sternocleidomastoid, neck muscle), thirty-six disease affected areas of thirty squamous cell cancers in head and neck was performed with CT perfusion scan; the experimental data was transmitted to Advanced Workstation4.1, GE perfusion3software was used to analyse the CT perfusion parameters (BF、BV\PS、MTT) of normal tissues in maxillofacial and neck tumors(tongue, parotid gland, submandibular gland, masticatory muscle, sternocleidomastoid, neck muscle),and the maximal slope of time-density curve(TDC); t-test was used to compare the differences of perfusion parameters between normal parotid gland and submandibular gland in normal side and suffered side; the differences of perfusion parameters was compared with the analysis of variance between squamous cell cancers and normal tissues in head and neck.2.The perfusion parameters of squamous cell cancers in head and neck with different degrees of differentiation higher, moderate, poorly) were compared to see differences.Results1. Statistics demonstrated that there is no differences between normal and affected submandibular glands, sternocleidomastoid muscle, masticatory muscle,and the neck muscle of tan, perfusion parameters.The highest rate of perfusion parameters tan,BF,BV,PS for normal tissues were submandibular glands, and it was followed by parotid gland, tongue, sternocleidomastoid muscle, masticatory muscle,and the neck muscle. MTT were from low to high.There was statistically significant differences between perfusion parameters of sternocleidomastoid muscle and the neck muscle (P<0.05)..For the perfusion parameters of squamous cell cancers in head and neck, they had significant differences compared with sternocleidomastoid muscles, masticatory muscles, and the neck muscles (P<0.01). The perfusion parameters of squamous cell cancers in head and neck with different degrees of differentiation(higher, moderate, lower) had a trend from low to high, there are significant differences between every two differentiation SCCA on tan. BF.BV(P<0.01).There was no difference on PS and MTT.and between higher and lower differentiation on tan, BF(P<0.01),and there was no difference on PS and MTT.Conclusions1. The perfusion parameters of submandibular gland and parotid gland were higher, and the perfusion parameters of stemocleidomastoid muscle. masticatory muscle and the neck muscle were lower, while the perfusion parameters of tongue were moderate.2. The differences of perfusion parameters were prominent between squamous cell cancers and normal muscles in head and neck. CT Perfusion Imaging has application value for differentiating squamous cell cancers in head and neck from normal tissues, which makes up the shortage of ordinary CT.3. The perfusion parameters of squamous cell cancers in head and neck with different degrees of differentiation(higher, moderate, lower) had a trend from low to high, there are significant differences between every two differentiation SCCA on tan, BF,BV. and between higher and lower differentiation on tan, BF(P<0.01).4. Among all the perfusion parameters, BF,BV,PS and MTT were found to have larger individual differences, values of tan were relatively stable, the average values of tan is better suited for identifying different normal tissues, as well as for distinguishing normal tissues from pathologic tissues.