Study On The Results Of Various Detection Models Of Voluntarily Donaned Blood

BackgroudBlood safety has become the global focus,and more attention of the transfusion safety has been payed.Screening the transfusion transmitted virus through blood testing is the basic strategy to protect the blood safty.About,all the country in the world have their own strategy of blood testing.And, to proteck the blood safety, different detection modes screening the transfusion transmitted virus have been drawn successively by many home scholars in rencent years.ObjectiveTo compare and statistically analyze the effects of different detection modes through retrospective analysis of the data of blood collection, distribution and test results of the donors;To find a scientific and rational combination of test items for different donation forms;To explore an economical and effective detection programs so as to reduce the positive rate of blood re-exam and lower the rate of scraped blood to achieve the purpose of saving resources and costs.Materials and MethodsA retrospective analysis of the blood collection data of2005and2009to2011in Shandong Blood Center was carried out by comparing the effect of different detection modes using statistical methods y2test. The health economics research was conducted by analyzing above mentioned data.(1) To find out the screening program through analysis of the test results and positive modes by screening mode2that without screening donors beforehand in2005.(2) To analyze the results of Unqualified blood, blood volume, volume of qualified blood, positive rate of retesting, differences of condemnation blood rate and the achieved results contrary to reagent costs after the implementation of new detection mode from2009to2011.(3) To study the differences in condemnation blood rate, reagent costs and the effects between those donating whole blood and those donating blood components. Main Results(1)In2005there were3534positives in61,809donors without pre-donation screening, and the positive rate in twice test was5.72%. ALT, HBsAg, HCV antibody, syphilis antibodies and other positive rates were2.44%,2.16%,0.70%,0.21%and0.21%respectively. In a total of11positive mode, the highest single positive rate was ALT, accounting for42.56%of all positive, followed by HBsAg(37.83%), HCV antibodies(12.28%), syphilis antibodies(3.65%) and others(3.65%). Strong association were detected between ALT and HBsAg, HCV antibody, syphilis antibodies. ALT and HBsAg demonstrated higher association than ALT and HCV antibodies.(2) After the implementation of different screening mode in2009, blood donors’positive rates of retesting from2009to2011were3.63%,3.56%and2.75%. The ALT positive rate were2.17%,2.30%and1.34%respectively in the3years. And HBsAg positive rate were0.42%,0.39%and0.35%. ALT and HBsAg positive rate declined significantly year by year compared to2005, and the reduction showed statistically significance. The blood abandonment rate from2009to2011were4.26%,3.43%and2.60%.The rate of retesting positive and condemnation blood rate displayed a declining trend after the application of detection mode2in2005.(3) For apheresis components of blood donors from2009to2011, the positive rate of re-examination by detection mode one was0.91%in2009contrasting0.22%and0.21%in2010and2011which using detection mode four and five. The rates of scraped component blood was0.61%,0.22%and0.18%, respectively during2009-2011.(4) Detection mode four can save the cost of585yuan in whole blood donation and527yuan in blood components donation in per100collection.Conclusions and Recommendations:Appropriate detection models for different donation forms can effectively reduce retesting positive rate, blood condemnation rate, blood wastage and the cost of reagents. Screening model4is better than other detection models and testing donors before blood collection using gold marked method rapid screening HBsAg is more effective than screening ALT.