A1:2Matched Case-control Study On Risk Factors Of Hypertension In An Island Population

Objective:This study surveyed and analysised risk factors of island residents cerebral infarction in Changhai county of Dalian,to research the potential risk factors of cerebral infarction, providing a reliable reference of the prevention and treatment of cerebral infarction for Dalian island residents.Methods:This investigatation used a1:2case-control study and cluster random sampling technique. All of the survey are island residents from islands of Changhai county in Dalian,Liaoning Province,participating in research by professional trained investigators, physicians, nurses and examiner.Related survey items project include questionnaires, physical examination, blood (morning fasting venous blood) and blood processing, preservation and inspection. According to1:2matched case-control study design principles analysis the cases meeting the diagnostic criteria.Controls were paired to cases with same nation,same sex,younger or older3years old and lived in the same area(island region).Inputing the meeting requirements of the original data into Excel2007establish a database,and adopting logistic regression model of risk factors for cerebral infarction analysis univariate and multivariate conditions logistic regression by the software of SPSS16.0or SAS9.1, using logistic regression analysis model of cerebral infarction risk factors analyzed by univariate and multivariate conditional Logistic regression analysis, then calculate the study factors and the strength of the association with cerebral infarction OR values and their95%CI.Results:Univariate logistic regression analysis results showed that:1,surveying a general condition found:occupation, family income, residence, family resident population have no statistical significance,cultural level have statistical significance (OR=1.538, OR95%CI=1.080～2.190).2, surveying family history,personal past history found:history of parents with hypertension, diabetes, heart disease,cerebrovascular disease have no statistical significance, the personal past history with coronary heart disease, high blood pressure, and whether medication for high blood pressure medication history, and recent (the past two weeks) were significantly different (OR=3.057, OR95%CI=1.344～6.951; OR=2.386, OR95%CI=1.116～5.102; OR=2.172, OR95%CI=1.043～4.524; OR=2.386, OR95%CI=1.116～5.120).3,measuring the various body values and detecting physical and biochemical parameters found:diastolic blood pressure (DBP), triglyceride (trig ’s), cholesterol (chol,), low density lipoprotein (1dlc), serum lipoprotein (the lpa), uric acid (UA) related to residents of the island regions of cerebral infarction in closely(P<0.05), but high-density lipoprotein (hdlc)(t=5.31, P<0.05) is protective factors for cerebral infarction.4, the consumption of cooking oil,cooking oil type,the sea food, alcohol was not statistically significant, the amount of salt (OR=17.772, OR95%CI=6.438～49.062) was cerebral infarction risk factor, pressure well water was a protective factor (OR=0.417, OR95%CI=.179～0.976), smoking (OR=.361, OR95%CI0.130～1.002) was significantly different, but not determine protective factor or risk factor.Multivariate logistic regression analysis showed that:diastolic blood pressure (OR=1.045, OR95%CI=1.013～1.076), coronary heart disease (OR=2.376, OR95%CI=.978to5.870), educational level (OR=1.546, OR95%CI=1.032～2.318) is the island regions of cerebral infarction the major risk factors, while high-density lipoprotein (OR=0.094, OR95%CI=0.023～0.377) is protective factors of cerebral infarction for the island residents.Conclusion:Diastolic blood pressure, education level, coronary heart disease, salty food are major risk factor for cerebral infarction of the island residents, while HDLC is a protec-tive factor. Therefore, the prevention and treatment of cerebral infarction in this area should be combined with the clinical characteristics of a targeted intervention to prevent from cerebral infarction occurring positively and effectively.