Analysis Of Frist Treatment Complete Remission Rate Relate Factors In30Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Objective:To investigate first treatment complete remission rate and its related factors of acute lymphoblastic leukemia(ALL).Methods:thirsty patients with ALL, from January2000to February2012in our hospital, were studied retrospectively.Univariate analysis of the potential factors influencing first treatment complete remission rate of these patients were carried out by comparison of the cases in same stage with chi square test.Prognostic indicators were demonstrated by CR rate.Results:12patients(40.0%) entered CR.The analysis of prognostic factors showed that:①There was no statistic difference in first treatment CR rate between male and female patients (P=0.361).②Significant differences of first treatment CR rate was found in different age groups(P=0.015),>30years-old patients CR is lower.③No difference caused by anemia、infection and bleeding features were found in CR rate (P=0.125,0.429,0.757respectively).④There were no significant differences of first treatment CR rate caused by hepatomegaly lymphadenectasis and sternal tenderness(P=0.661,0.456,0.880respectively),but significant difference can be found in splenomegaly and having central nervous system leukemia(P=0.011,0.033respectively).⑤The group with initial WBC<50×109/L had higher first treatment CR rate, the differences of first treatment CR rate between the group with WBC<50×109/L and that with WBC>50×109/L was great (P=0.009).⑥First treatment CR rate between two groups with different initial Hb levels showed no significant differences (P=0.543); There were no significant differences in first treatment CR rate between ALL patients with initial PLT≥50×109/L and those with initial PLT<50×109/L (P=0.543).⑦There were significant differences of first treatment CR rate in different AST、ALT and ALB groups(P=0.035,0.025,0.033respectively),but no significant differences can be found in different PA groups(P=0.765), also in diffrerent UA、Crea、TG and BS groups(P=1.000,0.937,0.577,0.707respectively).⑧Significant differences were found in first treatment CR rate of L1and L3groups,also L2and L3(P=0.029,0.013respectively), but first treatment CR rate of L1and L2showed no significant differences(P=0.912).⑨In groups of different induction regimen, There was no significant differences in frist treatment CR between COAP and VP(P=0.522), but Significant differences were found in first treatment CR rate of DOALP and COAP groups,also DOALP and VP(P=0.001,0.021respectively).Conclusion:Age, initial WBC count, splenomegaly, with central nervous system leukemia, AST, ALT, ALB, are all obviously relevant to first treatment CR rate of ALL. Factors, including age<30years old, initial WBC count<50×l09/L, no splenomegaly, without central nervous system leukemia,AST and ALT<40U/L, ALB>38g/l, indicate good first treatment complete remission rate. Classic marrow cellular morph-ology features and first treatment regimen are also relevant to first treatment CR rate of ALL, L3is the worst one of the diffrerent marrow cellular morph-ology groups, DOALP is the best one of the three regimens we observed.