The Expression And Implication Of STAT3, SOCS3and VEGF In Breast Cancer

[Objective]1. To explore the expression of STAT3，SOCS3and VEGF protein in breast cancerand its significance.2. To explore the difference of expression of STAT3，SOCS3and VEGF betweenpatients with breast cancer and those without breast cancer as control，in order to detectif there is separate or interactive effect on breast cancer.[Methods]Immunohistochemical SP staining method and tissue chip were adopted to researchthe expression of STAT3，SOCS3and VEGF in60cases of patients with breast cancerand those20without breast cancer as control. Multivariate logistic regression andspearman correlation were performed to analysis the relationship of these cases withtheir clinicopathologic characteristics, and the relationship among these three factors.[Results]1. The difference of positive expression of STAT3, SOCS3and VEGF wassignificant between patients with breast cancer and those without breast cancer ascontrol (P<0.05)；The difference of positive rate of VEGF was not significant betweenpatients with breast cancer and those without breast cancer as control（P>0.05）；Thepositive expression of STAT3and SOCS3did not appear to relate to clinicopathologiccharacteristics (P>0.05) including age, size of the tumor and migration. The positiveexpression of VEGF was related to clinicopathologic characteristics of migration(P<0.05). The positive expression of VEGF did not appear to relate to age and the sizeof breast cancer (P>0.05). There did not show significant negative correlation amongSTAT3, SOCS3and VEGF (P>0.05).2. STAT3and VEGF were risk factors of breast cancer and SOCS3is the protective factor of breast cancer.[Conclusion]There is high positive expression of STAT3and VEGF, and low positiveexpression of SOCS3, which suggests that these factors are concerned with thedevelopment of breast cancer so as to be contributed to prognostic judgment.