The Factors Involved In Diabetic Maculopathy Progress Analysis

Objective:Studying the factors involved in diabetic macular degeneration for earlyprevention of diabetic maculopathy.Methods:Retrospective analysis clinical data of114cases (177eyes) of diabetic patientsin January2011-February2013hospitalized in our hospital and clinics in ourhospital.177eyes of114patients were classified into five groups based onfluorescein fundus angiography (fundus fluorescence angiography, FFA) findings.The group of normal macular area:34eyes (19.2%,34/177); the group of maculararch ring integrity:9eyes (5.1%,9/177); the group of macular arch ring damaged:33eye (18.6%,33/177); the group macular edema:87eyes (49.2%,87/177) and thegroup of proliferation in macular area:14eyes (7.9%,14/177). Each patient’s age anddiabetes duration, smoking history, drinking history, whether regular exercise, bloodlipid, fasting blood glucose, glycosylated hemoglobin, urine trace albumin were tooknotes. All data were analysed by SAS9.1software of statistical analysis and dataprocessing, and studied the correlation between all factors and diabetic maculardegeneration progress.Result：1. The triglycerides, low density lipoprotein cholesterol of the macular edema groupwere significantly higher than those of the group of normal macular area, the groupof macular arch ring integrity and the group of macular arch ring damaged (P <0.05), and not no significant statistical difference Compared with macularproliferation group (P>0.05). Total cholesterol and apolipoprotein A1,apolipoprotein B, lipoprotein (a) of macular edema group were significantly higherthan those of the group of normal macular area, the group of macular arch ringintegrity,the group of macular arch ring damaged and the group of proliferation inmacular area (P <0.05). 2. The urea nitrogen of macular edema group was obviously higher than that of thegroup of macular arch ring damaged (P <0.05); the beta2–Mg and RBP of themacular edema group and the group of proliferation in macular area were higherthan those of the group of macular arch ring damaged (P <0.05); RBP of themacular edema and the group of proliferation in macular area was higher than thatof the group of normal macular area (P <0.05); A1b and alpha2-MG of themacular edema group were significantly higher than those of the group of normalmacular area, the group of macular arch ring integrity,the group of macular archring damaged and the group of proliferation in macular area (P <0.05).3. Diastolic pressure,height and waist circumference of macular edema group wereobviously higher than that of the group of macular arch ring damaged (P <0.05);diastolic pressure,height and waist circumference of the group of proliferation inmacular area were obviously higher than that of the group of macular arch ringdamaged (P <0.05). With the hip circumference increasing, diabetic maculardegeneration degree aggravating (the group of normal macular area, the group ofmacular arch ring integrity,the group of macular arch ring damaged, the macularedema group and the group of proliferation in macular area)(P <0.05).4. With the duration of hypertension course, the ratio of the number of patients ineach group was increased (P <0.05). With the duration of diabetes course, the ratioof the number of patients in each group was increased (P <0.05). With diabeticmaculopathy aggravating, the ratio of the number of patients by insulin increasedalso (P <0.05). With the duration of diabetic maculopathy course,eyesight wasdecreased (P <0.05). Along with the aggravating the degree of diabetic retinopathy,diabetic macular degeneration degree increased (P <0.05). In less than40ages, theratio of the number of diabetic maculopathy was increased (P <0.05). Conclusion:1. With blood sugar increasing, diabetic maculopathy aggravated, especially in thegroup of proliferation in macular area, but the macular edema group degeneratingand blood sugar was not directly related.2. With blood lipid levels increasing, diabetic maculopathy aggravated gradually.3. Urea nitrogen, urine trace albumin levels and diabetic maculopathy aggravationwas directly related.4. With the diastolic blood pressure, height, waist circumference, hip circumferenceincreasing, diabetic maculopathy aggravated gradually.5. With the history of high blood pressure and the duration of diabetes expanding,diabetic retinopathy aggravating, diabetic maculopathy degenerated. With degree ofdiabetic maculopathy degenerating, the ratio of the number of patients by insulinwas increased.