| Objective: To compare surgical treatment with non-surgicaltreatment for patients who suffered non-small cell lung cancer withsynchronous solitary brain metastasis.Methods: In this meta-analysis of observational studies, theliterature search was undertaken from January1,1990to March1,2013looking for studies evaluating the different survivals betweenpatients treated with surgical treatment with non-surgical treatment.We draw the details of trial design, characteristics of patients,outcomes and so on from the studies included. Date analysis wasperformed by RevMan5.0.Results: According to the same screening criteria,9clinicalstudies was included in this meta-analysis. In comparison withnon-surgical treatment, patients who had lung surgery got longersurvival [hazard ratio0.46, CI.950.32-0.67].Also in comparisonwith non-surgical treatment, patients who got brain surgery hadbetter prognosis[HR0.75,CI.950.61-0.91].It shows that patientswho had no lymph node metastasis had better prognosis [HR0.52,CI.950.39-0.70].Conclusion: Our meta-analysis provides evidence supporting thehypothesis that surgical treatment increases overall survival inpatients who suffered non-small cell lung cancer with synchronoussolitary brain metastasis. Patients who had no lymph node metastasiswill have better prognosis. |
