The Influence Of Mai-Xue-Kang To Plasma Lysophosphatidic Acid And Mononuclear Cell Toll-Like Receptor4in Stroke Blood Stasis Syndrome Patient

Objective:Plasma lysophosphatidic acid (LPA) levels and mononuclear cell Toll-like Receptor4(TLR4) express were determined to study the clinical effects and the role of MAI-XUE-KANG in blood stasis syndrome.Methods:65stroke blood stasis syndrome inpatients were randomly selected, and divided into two groups:MAI-XUE-KANG intervention group(33cases) and conventional treatment group(32cases),30cases of healthy people as blank control group. Observe the changes of the two group’s Toll-like Receptor4express and Plasma lysophosphatidic acid(LPA) levels, respectively, at1st,7th-day,14th-day after hospitalization, which were detected by flow cytometry and ELLSA, and the changes of scores of NIHSS and the stroke blood stasis diagnostic criteria(SBSDC).Results:1.7th and14th day LPA of conventional treatment group was significantly lower than that of the control group (P<0.05),conventional treatment group’s LPA on7th and14th day has no significant difference (P>0.05); control group’s LPA on1st,7th,14th day pairwise comparisons has significantly difference(P<0.05); conventional treatment group’s LPA on1st and7th day were compared,1st and14th day LPA were compared, has significant difference (P<0.05); conventional treatment group14th day LPA compared with normal control group, has no significant difference (P>0.05), the14th day LPA of the control group was significantly higher than the normal control group (P>0.05).2. Conventional treatment group on1st and7th day,1st and14th day of TLR4comparison,has significant differences (P<0.05); conventional treatment group on the7th and14th day of TLR4comparison,has no significant difference (P>0.05); the control group,1st,7th and14th day of TLR4pairwise comparisons,all have significant differences (P<0.05); conventional treatment group of TLR4on the7th and14th day, were significantly lower than the control group (P<0.05); two groups on14th day TLR4were significantly higher than the normal control group (P<0.05).3.In conventional treatment group compared1st and7th day,1st and14th day of NIHSS scores, has significant differences(P<0.05), the NIHSS score of7th and14th comparison has no significant difference((P>0.05); the control group,1st,7th and14th day of NIHSS score pairwise comparisons,all have significant differences (P<0.05); the14th day NIHSS score of conventional treatment group was significantly lower than that of the control group(P<0.05), and has significant differences in the efficacy of the two groups on the14th day(P<0.05).4. Both conventional treatment group and control group,1st and7th day,1st and14th day of blood stasis scores compared, has significant differences(P<0.05),7th and14th day of blood stasis scores compared, has no significantly difference(P>0.05). Blood stasis score of the14th day in conventional treatment group was significantly lower than the control group(P<0.05), and has significant differences in the efficacy of the two groups on the14th day(P<0.05).Conclusion:The increasing of LPA level and TLR4express is closely correlated with stroke blood stasis.MAI-XUE-KANG can effectively reduce related indicators of platelet activation and the related receptor-mediated immune and inflammatory response. Furthermore,both NIHSS and SBSDC scores after treatment decline significantly and may improve stroke blood stasis patient’s prognosis.