Toxicology Of "Xuanyunding Granules"

objective:To provide experimental evidence for the better application of Xuanyunding granules.method:1.Acute toxicity experiment Xuanyunding granules:The maximum concentration of the maximum volume administration, Compared with the distilled water control group, Observation on14consecutive days2. Xuanyunding granules long-term toxicity test:In Xuanyunding granules suspension at128.6g/kg/d,64.3g/kg/d,32.2g/kg/d crude drug, intragastric administration for4weeks,4weeks after the recovery period of observation, observation index of each animal body weight, blood routine, blood biochemistry, organ coefficient.result:1Acute toxicity experiment Xuanyunding granules:The maximum tolerance dose of mice by gastric Xuanyunding granules were calculated to be857.4g kg-1crude drug, which equal to342.9times of adult clinical oral daily dose.2. Long-term toxicity test Xuanyunding granules: During administration and withdrawal recovery period, Compared with distilled water control group, The SD activity of the rats, The growth of body weight, The indexes of Hematology and Biochemistry, Viscera index, histopathologic examination, They have no obvious abnormality. Conclusion:Xuanyunding granules within the scope of application of clinical medication safety...