The Clinical Application Of The Whole-body DWIBS A Primarily Study

[Objective] Evaluate the clinical application of Diffusion weighted whole body imaging with background body signal suppression (DWIBS) with comparison to SPECT and PET/CT.[Subjects and Methods] Sixty-five cases were divided into three groups:Group Ⅰ,35cases of bone metastasis, from40to79years old, including23cases before radiochemotherapy and12cases after radiochemotherapy. All primary focuses were proved by operation or biopsy. SPECT and DWIBS were also performed in all the cases within three days. Group Ⅱ,15cases of whole body metastasis, from37to77years old. All cases underwent PET and DWIBS. Group Ⅲ were normal control of15cases, from38to73years old. These cases only underwent DWIBS.MR scan was performed on GE1.5T Twin-Speed Infinity with Excite Ⅱ scanner. The raw data of DWIBS were processed offline on the Sun workstation AW4.0. SPECT scan was performed on GE Millennium UG8/CoDeⅡ/Hawkeye scanner, matrix was384X800. The patients had the examination three to four hours after injection of99mTc-MDP (925MBq). PET scan was performed on GE Discovery LS PET/CT scanner.18F-FDG (222-370MBq) was injected in an intravenous bolus. After injection, each subject should repose for45-60minutes before whole-body data acquisition.SPSS11.5was used to statistical analysis, the detailed content including:①Before radiochemotherapy, ADC among the lesions discovered by DWIBS and ECT were compared to normal bone adjacent to lesions in patient group and normal bone in control group.②Before radiochemotherapy, ADC and eADC between the lesions discorverd by DWIBS and ECT and the lesions discovered only by DWIBS were compared③The positive detection rate between DWIBS and ECT were compared④The ADC and eADC of the lesions discovered by DWIBS and ECT between before and after chemotherapy were compared.⑤After radiochemotherapy, the ADC and eADC were compared between the lesions discovered by DWIBS and ECT and normal bone in control group.⑥Compared with PET, the sensitivity and speciality of DWIBS were calculated.[Results]1. Before radiochemotherapy, the ADC and eADC among the three groups:the lesions discovered by DWIBS and ECT, normal bone adjacent to lesions in patient group and normal bone in control group showed significant difference. The ADC and eADC of the lesions discovered by DWIBS and ECT higher than the ADC and eADC of normal bone adjacent to lesions in patient group. Normal bone adjacent to lesions in patient group and normal bone in control group showed no significant difference.2. Before radiochemotherapy, the ADC and eADC of the lesions discovered by DWIBS and ECT and the lesions discovered only by DWIBS showed no significant difference.3. The ADC and eADC of lesions discovered by DWIBS and ECT after radiochemotherapy were lower than the ADC and eADC of lesions discovered by DWIBS and ECT before radiochemotherapy4. The ADC and eADC of lesions discovered by DWIBS and ECT after radiochemotherapy were higher than normal bone in control group5. Compared with PET, the sensitivity of DWIBS is85.7%and the speciality of DWIBS is98.4%[conclusion]1. The sensitivity and speciality of DWIBS in detecting osteolysis metastatic disease before radiochemotherapy is higher than SPECT. The sensitivity of DWIBS in monitoring the response of the disease to therapy is higer than SPECT. The ADC value of osteogenesis metastatic disease has decrease. The sensitivity and speciality of DWIBS in detecting whole body metastatic disease before radiochemotherapy is similar with PET/CT;2. The diagnosis of metastatic foci in chest and ribs is difficult.3. Anatomical orientation of the metastatic disease is difficult.