| PurposeTo evaluate the effect of PCI in the patients who get the anteriormyocardial infarction with ventricular aneurysm and the change of N-terminalB-type natriuretic peptide (NT-proBNP), serum high-sensitivity C-reactiveprotein (hs-CRP) in perioperative period of PCI and in30days after PCI,andwhether these factors could be early predictors of ventricular aneurysm.Method43cases with anterior myocardial infarction who underwent PCI, weredocumented from April2011to April2012at the General Hospital of ShenyangMilitary Region, including31males and12females, average aged58.3±12.1(55-69) years old; previous PCI, severe infection, tumors, rheumatic diseases, infectious disease, liver and renal insufficiency excluded. Based on leftventricular angiography, the patients were divided into ventricular aneurysmgroup(25cases,19were male and6female) and control group (18cases,12males and6females). All patients were got the blood serum sample ofhs-CRP、NT-proBNP before PCI, and hs-CRP12-16h or serum NT-proBNPafter48h. Ultrasonic cardiogram, ECG,serum NT–proBNP and hs–CRPwere followed up in one month. First of all, according to EF and left ventricularinternal diameter of1month after surgery in the ventricular aneurysm group,25people confirmed the significance of the PCI in ventricular aneurysm in patients.Followed by between ventricular aneurysm groups and control groups compare hs-CRP preoperative and postoperative12-16h, NT-proBNP preoperativepostoperative48h and after one month, making a comparison confirmed thaths-CRP and NT-proBNP for ventricular aneurysm in patients undergoing PCI ofthe predictive value.Results1. Compared pre-PCI and48h after PCI in Ventricular aneurysm group，the LVEF(Left ventricular eject fraction, LVEF;0.547±0.101vs0.565±0.092,P=0.513>0.05) and LVEDD (left ventricular diastolic diameter, LVEDD;52.52±6.838vs50.84±5.720P=0.351>0.05) were not significant difference.But there were significant difference of LVEF(0.547±0.101vs0.602±0.072,P=0.031<0.05) and LVEDD (52.52±6.838vs47.16±4.119P=0.002<0.05)between pre-PCI and one month after PCI.2. Compared to Control group, serum hs-CRP preoperative, postoperative12-16h in the ventricular aneurysm group were significant increase3.50(1.37-12.38) vs0.98(0.27-5.10),3.12(1.85-9.41) vs1.11(0.21-3.33),P valuewere0.012and0.01.3. Serum NT-proBNP pre-PCI,48h and a month after PCI in the ventricularaneurysm group were significant difference1173.00(518.75-1998.50) vs439.30(123.33-912.83),1008.00(625.70-1914.50) vs331.05(138.75-781.08)，658.00(498.00-1184.00) vs349.00(114.25-534.00),P value=0.013,0.01,0.003.Conclusion1.PCI can improve heart function to anterior myocardial infarction with Leftventricular aneurysm patients.2.Serum hs-CRP and NT-proBNP maybe predictive value for anteriormyocardial infarction with Left ventricular aneurysm patients... |
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