Dominant Eye And Non-dominant Eye With Age-related Cataract Morbidity

Objective:To investigate the relationship of dominant eye and non-dominant eye with age-related cataract, and to provide some new ideas and theories for age-related cataract pathogenesis and treatment.Methods:Slected a total of30patients with60eyes of age-related cortical cataract (Age-related cataract, ARC), with lesions similar and the visual difference of double eyes no more than two lines as the standard; aged from53to84years, mean (69.2±8.9) years old. Double eyes phacoemulsification plus intraocular lens implantation. A week before and after surgery to determine dominant eye and non-dominant eye;measured the lens thickness changes of double eyes in its natural state and after miosis before surgery; taken the central anterior lens capsule in surgery to do the HE staining, counted the lens capsule epithelial cells (Lens epithelial cells, LEC);and TEM observed dominant eye and non-dominant eye ultrastructural changes of the LEC. Normal contrast group was the health of the donor corneal transplant eye lens capsule of4patients, aged from28to40years, mean34years old, the LEC count after HE staining.Results:30patients in case group mean visual acuity:dominant eye (0.34±0.11), non-dominant eye (0.35±0.12), before and after surgery the dominant eye did not change; the lens thickness changes of dominant eye group and the group of non-dominant eye in the natural state and after miosis were significant difference (P <0.01); dominant eye group and the group of non-dominant eye LEC density was (3606±429) a/mm2and (3913±433)a/mm2, the difference was significant (P<0.01). LEC average density of normal contrast group was (4735±108) a/mm2, the difference compared with the case group was significant (P<0.01); TEM observation:the LEC density of dominant eye lower than the non-dominant eye, different size and shape of epithelial cells, abnormal cells showed increased cell space, and even showed vacuolar changes, mostly round nuclei, some cells organelle swelling, membrane dissolution; part of the cell shrinkage, chromatin condensation around the technology, showing early apoptotic changes. Conclusion:The lens thickness of dominant eye in the visual activities was significantly larger than the non-dominant eye; the LEC average density of dominant eye less than the non-dominant eye; LEC density of ARC patients was significantly lower than the normal contrast group. ARC is earlier in the dominant eye, suggesting that the reasons for its use in daily visual activities, the regulation of large, large amount of light entering the eye, causing changes in the microenvironment within the eye, causing damage to LEC, leading to cell density reduced, leading to cataracts.