Sinomenine On Rabbit Atherosclerotic Tissues Of MPGES-1Expression In Experimentalis Studio

Objective:The study found that the severity of atherosclerosis and its organization of mPGES-1expression into the correlation. Sinomenine has a good immune suppression and anti-inflammatory effects and atherosclerosis treatment. Observe the impact of sinomenine on rabbit atherosclerosis, and to explore the study of sinomenine atherosclerotic rabbit arteries organization of mPGES-1expression mechanism. In order to further expand the application of sinomenine, sinomenine in the arterial atherosclerotic cardiovascular disease application basisMethods:48common domestic rabbit, half male and half female, Randomized, six blank, high fat diet atherosclerotic model group, high fat diet fed for three months, rabbit occurrence of arterial atherosclerotic lesions. Check the rabbit lipid biochemical indicators of change and remove the four quickly put to death, take the common carotid artery tissue for pathological observation randomly from the. high fat diet atherosclerosis model group, the atherosclerotic lesion formation. Post sculptured pro medicament interventu in hederam alkalis et Zhibituo de IG observer seemly a septimana pondus mutatio. Post administrationem, cor sanguine, sanguinem lipids et diam deprehendatur. Collecta sanguinem exempla, accipere ius et sinistram acaroids in lepus organizationem, parte histopathological Insecta observari, parte de RT-PCR, et severe organizationem sinomenine in lepus acaroids AS de mPGES-I mRNA expression.Results:1. A blank coetus cum princeps adipem victu AS exemplar coetus, lux minimum pathologia observavit, blank coetus lepus a.carotis sine AS laesiones, dum princeps adipem victu AS exemplar coetus, in atherosclerotic laesiones, prospere sculpturae.2. Analysis in notitia observari in Tabula Ⅲ, lepus lipidorum diam Indicatores de TG, TC et LDL-C comparatur ad blank coetus infima, secuti per imperium coetus, sinomenine, humilis-dose coetus. HDL-C coetus cum blank coetus. secuti per imperium coetus, sinomenine, humilis-dose coetus.3. Analysis sinomenine, humilis-dose coetus, lepus acaroids AS ordo mPGES-I mRNA expression, in sinomenine princeps dose coetus minimum, secuti per medium dose coetus, humilis dose coetus expressionem servari Tabula IV summa.Conclusion:Sinomenine on the treatment of atherosclerosis mechanisms as follows:sinomenine by the inhibition of the immune, so that peripheral blood CD4T-cell proliferation was inhibited to reduce the proinflammatory cytokines such as TNF-α, IL-1β and LPSsecretion, and thus reduction of mPGES-1mRNA and mPGES-Ⅰ protein expression. Resulting in PGE2synthesis to reduce the inflammation blocked by atherosclerosis was inhibited. The progress of atherosclerosis was inhibited, and atherosclerotic plaque stability is enhanced.