Research On β-Lactam Antibiotics And Intermediate Degredation Passway

Currently β-lactam antibiotics have good application effect in anti-bacterial infection andthey are applied widely.The β-lactam antibiotics pharmaceutical market is booming.Thedemand of β-lactam antibiotics drugs is increasing and the rapid growth of output andvarieties are very considerable. But some studies have shown that a large number of β-lactamantibiotics and intermediates existing in the environment are harmful to human health andecosystem. Therefore, it’s necessary to research the degradation law of β-lactam antibioticsand intermediate.In this study ceftriaxone sodium, cefoperazone sodium, ampicillin sodium, amoxicillin,6-APA and7-ACA were chosen as the analytes.The hydrolysis and adsorption behavior rulesin different temperature and pH value conditions of β-lactam antibiotics and intermediateswere carried out respectively. Additionally, the β-lactam antibiotics and intermediate removalefficiency in different carbon sources, temperature, dissolved oxygen, pH value conditionswere inspected integratedly and the optimum processing conditions were obtained.The research of β-lactam antibiotics and intermediate hydrolysis behavior rules indicatedthat the half-lives of β-lactam antibiotics and intermediate shortened and hydrolysis ratesaccelerated with temperature and pH value rising. The β-lactam antibiotics and intermediatewere hydrolyzed rapidly under weak alkali conditions and they were more stable under acidicconditions. The pH value changes had obviously effect upon hydrolysis rates of β-lactamantibiotics and intermediate. Light could only play a very weak role in promoting thehydrolysis of beta-lactam antibiotics and intermediates. It is not the main removal pathway ofthese analytes.The research of β-lactam antibiotics and intermediate adsorption behavior rulesdemonstrated that solution could achieve adsorption balance after4h. The temperature and pHvalue had a certain influence on the adsorption of β-lactam antibiotics and intermediate.Hightemperature was disadvantageous for adsorption of β-lactam antibiotics and intermediate andpH value too high or low was also unfavorable to their adsorption.The paper examined the β-lactam antibiotics and intermediate degradation effect usingaerobic activated sludge system synthetically. Glucose, sucrose and starch were selected asexternal carbon source, and the results showed that the removal effect of β-lactam antibiotics and intermediate was best when glucose was used as plus carbon source. The optimum massratio of glucose and analytes was1:8. During the experiment, the reaction condition werecontrolled as follows: temperature15℃,25℃and35℃; pH value5,7and9; dissolvedoxygen1,2.5and4mg/L.Finally, considering the treatment effect and the processing costfactors, then gained a relatively appropriate condition: controlling temperature at25to35℃,pH value in neutral and dissolved oxygen for2.5mg/L.