| Objective:Through the study on the affection of Ginseng Tiaopi powder ([Z06602019word system of Fujian medicine] Zhangzhou Hospital of Traditional Chinese Medicine preparation center production)on serum gastrin in patients with functional dyspepsia (FD),discussed the mechanism of action of Ginseng Tiaopi powder on FD;The efficacy results were observed and analyzed providing reliable experimental datas for the expansion of the medicine use on clinical therapeutic indications.Methods:This topic through the collection of60patients inculding outpatients and inpatients with functional dyspepsia consistent with diagnostic standard,according to random, single blind, controlled experiment principle,60patients were randomly divided into proprietary chinese medicine group and controlled group with each group30cases. Proprietary chinese medicine group was given Ginseng Tiaopi powder6g tid while controlled group received domperidone chip10mg tid. Both of them were taken orally30minites before meals.The whole treatment was for two courses with2weeks a course.Serum gastrin levels were mersured before and after treatment also the curative effect was observed in this study.Results:Firstly,serum gastrin levels of both groups declined after treatment and the descend degree of two groups had no significant differences(p>0.05).Next,the total response rate received in proprietary chinese medicine group was higher than those of controlled group (80%vs53.33%,respectively,p<0.01). There were significant differences in total symptom scores in two groups between before and after treatment(p<0.01).The symptom scores were improved.Moreover,the improving rate of proprietary chinese medicine group was higher than those of the other group. Changes on eructation and heartburn of two groups were obvious especially on heartburn syndrome.Changes on early satiety and postprandial fullness of proprietary chinese medicine group were obvious which were not so obvious in controlled group(p<0.01).Neither proprietary chinese medicine group nor controlled group had significant differences on upper abdominal pain before and after treatment. Last but not the least,Ginseng Tiaopi powder had no obvious adverse reaction during the treatment that it had long term safety tips.Patients’ temperature,heart rate,respiration,blood pressure had no significant fluctuations before and after treatment.The blood,urine,excrement routine,liver,renal function, electrocardiogram, abdominal ultrasound B were similar before and after treatment.Conlucsions:1.Ginseng Tiaopi powder may reduce serum gastrin level.2.Gingseng Tiaopi powder has obvious effects on the treatment of postprandial distress syndrome (PDS) of functional dyspepsia.3. Ginseng Tiaopi powder has no obvious adverse reaction during the treatment that it has long term safety tips. |
