Study On Correlation Of Phthalate Esters Exposure With Endometriosis And Leiomyomas In Childbearing Aged Women

ObjectiveProviding evidence and clue for further studying how phthalate esters(PAEs) affect the female reproductive system by analyzing the data about the urinary concentration of the phthalate metabolites which from the women suffering from endometriosis and uterine leiomyomas. All women consulted the General Hospital of Tianjin Medical University for treatment. Using SPE-high liquid chromatography measured the concentration of phthalate metabolites in urinary samples and evaluated the onset risk of endometriosis and uterine leiomyomas which caused by PAEs.MethodsThis study, ruling out occupational exposure of PAEs, collected the urine samples of35women suffering from EMs and46normal women as controlled case during March to October2011from the General Hospital of Tianjin Medical University. At the same time, collected the urine samples of28women suffering from leiomyomas and27normal women as controlled case. All the samples were kept80degree under zero, and complete the questionnaires including these women’s basic information(age, height, menses, education and families). We used logistic regression to estimate odds ratios (ORs) and95%confidence intervals (CIs), adjusting for potential confounders.Results(1) Evaluated the onset risk of EMs in childbearing age women caused by the exposure of PAEs:the phthalate monoesters were detected in all samples; compared with the control, the age at menarche was lower (P<0.05) and the duration of menstrual bleeding was longer (P<0.05) in the case group; significant positive associations were found for the urinary creatinine-unadjusted concentrations of MBP and MEHP in the case group (P<0.05), the ORs of urinary MBP were1.006(95%CI,1.001-1.012, P<0.05) for EMs, the ORs of urinary MEHP were1.039(95%CI, 1.006-1.073, P<0.05); significant positive difference were found for urinary creatinine-adjusted concentrations of MBP,(P<0.05), no association was found between the exposure of PAEs and EMs.(2) Evaluated the onset risk of leiomyomas in childbearing age women caused by the exposure of PAEs:compared with the control, the BMI was higher in the case group (P<0.01); significant positive associations were found for the urinary creatinine-unadjusted concentrations of MBP in the case group (P<0.01), the ORs of urinary MBP were1.012(95%CI,1.001-1.024, P<0.05) for leiomyomas, the exposure of DBP increased the risk of leiomyomas; significant positive associations were found for the urinary creatinine-adjusted concentrations of MBP in the case group (P<0.05), the urinary MBP were1.009,(95%CI,1.001-1.017, P<0.05), the exposure of DBP increased the risk of leiomyomas.Conclusion(1) We found no association between urinary phthalate monoesters concentrations and endometriosis;(2) we found the exposure of DBP increase the risk of uterine leiomyomas.