Retropective Analysis On Risk Factors Of Neutropenia In Patients With Gestational Trophoblastic Disease And Received Chemotherapy

Objective To evaluate the risk and prevention of chemotherapy-inducedneutropenia grade≥2which had occurred in gestational trophoblastic diseasepatients.Methods The potential risk factor related to neutropenia was managedby univiriate analysis in122patients of gestational trophoblastic disease whoreceived chemotherapy.The factors which had signigicance (P＜0.1) wereselected to be done by logistic regression analysis.Results The total incidence rate of neutropenia grade≥2was36.6%.During univariate analysis,age,disease stage, prior chemotherapy, baselineanemia,baseline low platelets count,low serum albumin,hyperbilirubinemia andfever were unrelated to neutropenia grade≥2(P＞0.1).Body surface area,tumourtype,chemotherapy regimen,high aspartate aminotransferase aminotransferaseand serum creatinine had a certain correlation with neutropenia grade≥2(0.01＜P＜0.1）.Prognostic score, baseline leucopenia,baseline neutropenia,high alanineaminotransferase and primary CSF prophylaxis were relevant with neutropeniagrade≥2significantly(P＜0.01）.During the multivariate analysis, baselineneutropenia, high alanine aminotransferase and high serum creatinine were the independent risk factors.Conclusion It should be fully recognized the independent risk factors ofchemotherapy-induced neutropenia grade≥2which had occurred in gestationaltrophoblastic disease patients.It is help to give correct and timely preventivetreatment to ensure chemotherapy successfully,elevate the efficacy and improvepatients′prognosis.