The Association Of Serum Prostate-specific Antigen Levels With Metabolic Syndrome And Its Components In Guangxi Fangchenggang Population

Research background and objectives: Current evidence fromepidemiological and clinical studies implied that the incidence of prostatecancer and Metabolic Syndrome in China had increased year by year,which had become the main threats to human public health problem.Prostate-Specific Antigen (PSA) was an important mean of diagnosingprostate cancer, however, it could be impacted by many factors includingMS etc. The relationship between serum PSA levels and MS and itscomponents was still unclear. Especially there was still lack of a large sample of epidemiological survey in Chinese, which of the incidence ofprostate cancer was low. In order to study the relationship between serumPSA levels and MS in Asia especially in China, we employed themethodology of epidemiological cross-sectional survey.Study design and statistical method: Fangchenggang Area MaleHealth and Examination Survey (FAMHES) was a community-basedcross-sectional study involving male adult residents in Guangxi, China. Atotal of4303subjects who received routine healthy check-up in the medicalcenter of Fangchenggang First People’s Hospital from September2009toDecember2009. Baseline information such as demographic characteristics,lifestyle factors, history of surgeries and medication were assessed by usingstandard design lifestyle questionnaire. The height, weight, waistcircumference (WC), blood pressure were measured by trained personnelusing a standardized protocol. Overnight fasting venous blood specimenswere drawn. Triglycerides (TG), High-Density lipoprotein cholesterol(HDL-C), Fasting Blood Glucose (FBG) and PSA were measuredenzymatically on an automatic analyzer. Rank-sum test, Chi-square,Spearman and Partial correlation analysis were used in the study.Result: There were181(8.9%) subjects with MS. The serum PSAlevels showed significantly different between the subjects with MS (0.70,0.48-0.97) and those of Non-MS (0.76,0.54-1.07)(P<0.05). In differentPSA levels (<1.0ng/ml,1.0-1.9ng/ml,≥2.0ng/ml), there was not statistically significant difference between MS group and Non-MS group. Itwas the same as between serum PSA levels and MS scores (r=0.039,P>0.05). Spearman analysis showed that: there was negative correlationbetween PSA levels and MS, body mass index (BMI), WC (P <0.05).However, there was not significant correlation between PSA levels andblood pressure, FBG, TG, HDL-C. On each components of the MS, onlycentral obesity showed low PSA levels (P=0.002). After adjustment forage, blood pressure, FBG, TG, HDL-C, partial correlation analysis showedthat there was still negative correlation between PSA levels and MS (P <0.05). After adjustment for BMI and WC, there was no significantcorrelation between PSA levels and MS (P value was0.203and0.099, both>0.05).Conclusions: On each components of the metabolic syndrome, onlycentral obesity showed low serum PSA levels. So when using serum PSAlevels as screening standards to diagnose prostate cancer in MS patientswith central obesity, central obesity should be considered as a factorassociated with lower serum PSA levels.